Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
DELTA1-56 | 3.35fold increase in KM-value for pyridoxamine 5'-phosphate compared to wild-type enzyme, 2.95fold increase in KM-value for pyridoxine 5'-phosphate compared to wild-type enzyme, 6fold increase in KI-value for pyridoxal 5'-phosphate compared to wild-type enzyme | Homo sapiens |
DELTA238-262 | inactive mutant enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
pyridoxamine 5'-phosphate | pH 8.0, 25°C, wild-type enzyme | Homo sapiens | |
0.0062 | - |
pyridoxine 5'-phosphate | pH 8.0, 25°C, wild-type enzyme | Homo sapiens | |
0.0062 | - |
pyridoxamine 5'-phosphate | pH 8.0, 25°C, mutant enzyme DELTA1-56 | Homo sapiens | |
0.0208 | - |
pyridoxine 5'-phosphate | pH 8.0, 25°C, mutant enzyme DELTA1-56 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | 0.7% of the activity in liver | Homo sapiens | - |
adrenal gland | 11.5% of the activity in liver | Homo sapiens | - |
amygdala | 13.0% of the activity in liver | Homo sapiens | - |
aorta | 1.2% of the activity in liver | Homo sapiens | - |
atrium | 14% of the activity in liver detected in left atrium, 11.6% of the activity in liver detected in tight atrium | Homo sapiens | - |
bladder | 6.8% of the activity in liver | Homo sapiens | - |
bone marrow | 11.2% of the activity in liver | Homo sapiens | - |
brain | 23.8% of the activity in liver | Homo sapiens | - |
caudate nucleus | 19.0% of the activity in liver | Homo sapiens | - |
caudate putamen | 2.0% of the activity in liver | Homo sapiens | - |
cerebellum | 13.3% of the activity in liver detected in left cerebellum, 25.0% of the activity in liver detected in the right cerebellum | Homo sapiens | - |
cerebral cortex | 25.9% of the activity in liver | Homo sapiens | - |
cerebral gyrus | of cerebral cortex, 9.5% of the activity in liver | Homo sapiens | - |
colon | 1.2% of the activity in liver detected in ascending colon, 7.9% of the activity in liver is detected in transverse colon, 2.8% of the activity in liver is detected in descending colon | Homo sapiens | - |
corpus callosum | 18.4% of the activity in liver | Homo sapiens | - |
DAUDI cell | 1.1% of the activity in liver | Homo sapiens | - |
duodenum | 9.3% of the activity in liver | Homo sapiens | - |
esophagus | 7.5% of the activity in liver | Homo sapiens | - |
frontal lobe | 12.4% of the activity in liver | Homo sapiens | - |
heart | 3.7% of the activity in liver | Homo sapiens | - |
HeLa-S3 cell | 3.5% of the activity in liver | Homo sapiens | - |
hippocampus | 12.3% of the activity in liver | Homo sapiens | - |
HL-60 cell | 2.3% of the activity in liver | Homo sapiens | - |
ileocecum | 6.1% of the activity in liver | Homo sapiens | - |
ileum | 5.8% of the activity in liver | Homo sapiens | - |
interventricular septum | 16.2% of the activity in liver | Homo sapiens | - |
jejunum | 13.3% of the activity in liver | Homo sapiens | - |
K-562 cell | 2.5% of the activity in liver | Homo sapiens | - |
kidney | 85.6% of the activity in liver | Homo sapiens | - |
left ventricle | 4.1% of the activity in liver detected in the left ventricle | Homo sapiens | - |
leukocyte | from peripheral blood, 0.4% of the activity in liver | Homo sapiens | - |
liver | 30.2% of the activity of adult liver is detected in foetal liver | Homo sapiens | - |
lung | 4.6% of the activity in liver | Homo sapiens | - |
lymph node | 4.6% of the activity in liver | Homo sapiens | - |
medulla oblongata | 5.0% of the activity in liver | Homo sapiens | - |
MOLT-4 cell | 8.1% of the activity in liver | Homo sapiens | - |
nucleus accumbens | 5.2% of the activity in liver | Homo sapiens | - |
occipital lobe | 14.7% of the activity in liver | Homo sapiens | - |
ovary | 4.3% of the activity in liver | Homo sapiens | - |
pancreas | 2.5% of the activity in liver | Homo sapiens | - |
parietal lobe | 13.6% of the activity in liver | Homo sapiens | - |
placenta | 30.2% of the activity in liver | Homo sapiens | - |
pons | 6.2% of the activity in liver | Homo sapiens | - |
prostate gland | 16.5% of the activity in liver | Homo sapiens | - |
RAJI cell | 6.5% of the activity in liver | Homo sapiens | - |
rectum | 2.3% of the activity in liver | Homo sapiens | - |
right ventricle | 20.5% of the activity in liver detected in the right ventricle | Homo sapiens | - |
salivary gland | 10% of the activity in liver | Homo sapiens | - |
skeletal muscle | 34.1% of the activity in liver | Homo sapiens | - |
spinal cord | 1.6% of the activity in liver | Homo sapiens | - |
spleen | 13.5% of the activity in liver | Homo sapiens | - |
stomach | 17.2% of the activity in liver | Homo sapiens | - |
SW-480 cell | 5.1% of the activity in liver | Homo sapiens | - |
temporal lobe | 12.6% of the activity in liver | Homo sapiens | - |
testis | 8.4% of the activity in liver | Homo sapiens | - |
thalamus | 10.8% of the activity in liver | Homo sapiens | - |
thymus | 6.4% of the activity in liver | Homo sapiens | - |
thyroid gland | 20.3% of the activity in liver | Homo sapiens | - |
trachea | 4.8% of the activity in liver | Homo sapiens | - |
uterus | 2.9% of the activity in liver | Homo sapiens | - |
vermiform appendix | 0.7% of the activity in liver | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyridoxamine 5'-phosphate + H2O + O2 | - |
Homo sapiens | pyridoxal 5'-phosphate + NH3 + H2O2 | - |
? | |
pyridoxine 5'-phosphate + H2O + O2 | - |
Homo sapiens | pyridoxal 5'-phosphate + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PNPO | - |
Homo sapiens |
pyridoxine 5'-phosphate oxidase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
3.8 | - |
pyridoxal 5'-phosphate | pH 8.5, 25°C, pyridoxine 5'-phosphate as substrate, wild-type enzyme | Homo sapiens | |
23 | - |
pyridoxal 5'-phosphate | pH 8.5, 25°C, pyridoxine 5'-phosphate as substrate, mutant enzyme DELTA1-56 | Homo sapiens |