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Literature summary for 1.4.3.3 extracted from

  • Hin, N.; Duvall, B.; Berry, J.F.; Ferraris, D.V.; Rais, R.; Alt, J.; Rojas, C.; Slusher, B.S.; Tsukamoto, T.
    D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold (2016), Bioorg. Med. Chem. Lett., 26, 2088-2091 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.3

Inhibitors

Inhibitors Comment Organism Structure
2-[[(3,4-dichlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
3-(7-hydroxy-2-oxo-4-phenyl-2H-1-benzopyran-6-yl)propanoic acid
-
 Homo sapiens
3-(benzylsulfanyl)-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-benzyl-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[(cyclohexylmethyl)sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[(1,2-benzoxazol-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[(2H-1,3-benzodioxol-5-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[(3,4-dichlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[(4-chlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[(4-tert-butylphenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[(6-fluoronaphthalen-2-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[([1,1'-biphenyl]-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
3-[[([1,1'-biphenyl]-4-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one
-
 Homo sapiens
4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
5-hydroxy-3-(2-phenylethyl)-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
5-hydroxy-3-(3-phenylpropyl)-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
5-hydroxy-3-[(2-phenylethyl)sulfanyl]-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
5-hydroxy-3-[[(4-iodophenyl)methyl]sulfanyl]-1,2,4-triazin-6(1H)-one
-
 Homo sapiens
5-hydroxy-4-methyl-3-[(naphthalen-1-yl)methyl]pyridine-2,6(1H,3H)-dione
-
 Homo sapiens
6-[2-(3,5-difluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Ser + H2O + O2 Homo sapiens
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ser + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
DAAO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003
-
 pH and temperature not specified in the publication Homo sapiens 3-[[(4-chlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.00003
-
 pH and temperature not specified in the publication Homo sapiens 3-[[(6-fluoronaphthalen-2-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.00005
-
 pH and temperature not specified in the publication Homo sapiens 3-[[(3,4-dichlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.00005
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-3-[[(4-iodophenyl)methyl]sulfanyl]-1,2,4-triazin-6(1H)-one
0.00006
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-3-(2-phenylethyl)-1,2,4-triazin-6(1H)-one
0.00006
-
 pH and temperature not specified in the publication Homo sapiens 3-[[(2H-1,3-benzodioxol-5-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.00007
-
 pH and temperature not specified in the publication Homo sapiens 3-benzyl-5-hydroxy-1,2,4-triazin-6(1H)-one
0.00009
-
 pH and temperature not specified in the publication Homo sapiens 3-[[([1,1'-biphenyl]-4-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.0001
-
 pH and temperature not specified in the publication Homo sapiens 3-(benzylsulfanyl)-5-hydroxy-1,2,4-triazin-6(1H)-one
0.0002
-
 pH and temperature not specified in the publication Homo sapiens 3-[[(1,2-benzoxazol-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.0003
-
 pH and temperature not specified in the publication Homo sapiens 3-[[(4-tert-butylphenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.0006
-
 pH and temperature not specified in the publication Homo sapiens 3-[(cyclohexylmethyl)sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.0007
-
 pH and temperature not specified in the publication Homo sapiens 3-[[([1,1'-biphenyl]-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
0.004
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-3-(3-phenylpropyl)-1,2,4-triazin-6(1H)-one
0.04
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-3-[(2-phenylethyl)sulfanyl]-1,2,4-triazin-6(1H)-one