Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-hydroxyquinoline-2-(1H)-one | very potent inhibitor | Homo sapiens | |
4H-furo[3,2-b]pyrrole-5-carboxylic acid | - |
Homo sapiens | |
4H-thieno[3,2-b]pyrrole-5-carboxylic acid | - |
Homo sapiens | |
5-methylpyrazole-3-carboxylic acid | - |
Homo sapiens | |
6-chlorobenzo[d]isoxazol-3-ol | - |
Homo sapiens | |
anthranilate | - |
Homo sapiens | |
benzoate | competitive inhibitor | Homo sapiens | |
chlorpromazine | - |
Homo sapiens | |
D-serine | - |
Homo sapiens | |
trifluoro-D-alanine | pseudo-substrate | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.3 | - |
D-alanine | at pH 7.0 and 25°C | Homo sapiens | |
1.5 | - |
D-tryptophan | at pH 7.0 and 25°C | Homo sapiens | |
1.5 | - |
D-Dopa | at pH 7.0 and 25°C | Homo sapiens | |
1.5 | - |
D-tyrosine | at pH 7.0 and 25°C | Homo sapiens | |
2.7 | - |
D-phenylalanine | at pH 7.0 and 25°C | Homo sapiens | |
7.5 | - |
D-serine | at pH 7.0 and 25°C | Homo sapiens | |
8.5 | - |
D-proline | at pH 7.0 and 25°C | Homo sapiens | |
180 | - |
glycine | at pH 7.0 and 25°C | Homo sapiens | |
2000 | - |
D-Aspartate | at pH 7.0 and 25°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-amino acid + H2O + O2 | Homo sapiens | - |
2-oxocarboxylate + NH3 + H2O2 | - |
? | |
D-kynurenine + H2O + O2 | Homo sapiens | - |
kynurenic acid + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | Homo sapiens | low catalytic efficiency and substrate affinity on the physiological substrate D-serine | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain cortex | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
glial cell | - |
Homo sapiens | - |
medulla oblongata | - |
Homo sapiens | - |
additional information | not detected in the forebrain | Homo sapiens | - |
pons | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | - |
Homo sapiens | pyruvate + NH3 + H2O2 | - |
? | |
D-amino acid + H2O + O2 | - |
Homo sapiens | 2-oxocarboxylate + NH3 + H2O2 | - |
? | |
D-aspartate + H2O + O2 | - |
Homo sapiens | oxaloacetate + NH3 + H2O2 | - |
? | |
D-DOPA + H2O + O2 | - |
Homo sapiens | 3,4-dihydroxyphenylpyruvic acid + NH3 + H2O2 | - |
? | |
D-kynurenine + H2O + O2 | - |
Homo sapiens | kynurenic acid + NH3 + H2O2 | - |
? | |
D-phenylalanine + H2O + O2 | - |
Homo sapiens | phenylpyruvate + NH3 + H2O2 | - |
? | |
D-proline + H2O + O2 | - |
Homo sapiens | 2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
D-serine + H2O + O2 | low catalytic efficiency and substrate affinity on the physiological substrate D-serine | Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
D-tryptophan + H2O + O2 | - |
Homo sapiens | indol-3-pyruvic acid + NH3 + H2O2 | - |
? | |
D-tyrosine + H2O + O2 | - |
Homo sapiens | 4-hydroxyphenylpyruvic acid + NH3 + H2O2 | - |
? | |
glycine + H2O + O2 | - |
Homo sapiens | glyoxylate + NH3 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
D-amino acid oxidase | - |
Homo sapiens |
DAAO | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.9 | - |
glycine | at pH 7.0 and 25°C | Homo sapiens | |
3 | - |
D-serine | at pH 7.0 and 25°C | Homo sapiens | |
3.2 | - |
D-tryptophan | at pH 7.0 and 25°C | Homo sapiens | |
5.2 | - |
D-alanine | at pH 7.0 and 25°C | Homo sapiens | |
6.6 | - |
D-phenylalanine | at pH 7.0 and 25°C | Homo sapiens | |
6.7 | - |
D-Aspartate | at pH 7.0 and 25°C | Homo sapiens | |
10.2 | - |
D-proline | at pH 7.0 and 25°C | Homo sapiens | |
14.8 | - |
D-tyrosine | at pH 7.0 and 25°C | Homo sapiens | |
21.7 | - |
D-Dopa | at pH 7.0 and 25°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
benzoate | at pH 7.0 and 25°C | Homo sapiens | |
0.7 | - |
chlorpromazine | at pH 7.0 and 25°C | Homo sapiens | |
0.7 | - |
trifluoro-D-alanine | at pH 7.0 and 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000004 | - |
at pH 7.0 and 25°C | Homo sapiens | 3-hydroxyquinoline-2-(1H)-one | |
0.000141 | - |
at pH 7.0 and 25°C | Homo sapiens | 4H-furo[3,2-b]pyrrole-5-carboxylic acid | |
0.000145 | - |
at pH 7.0 and 25°C | Homo sapiens | 4H-thieno[3,2-b]pyrrole-5-carboxylic acid | |
0.00018 | - |
at pH 7.0 and 25°C | Homo sapiens | 6-chlorobenzo[d]isoxazol-3-ol | |
0.00091 | - |
at pH 7.0 and 25°C | Homo sapiens | 5-methylpyrazole-3-carboxylic acid |
General Information | Comment | Organism |
---|---|---|
malfunction | a total loss of enzymatic activity is associated with the adult onset of familial amyotrophic lateral sclerosis. Altered enzyme expression levels and activity have been reported in schizophrenia | Homo sapiens |
physiological function | the enzyme is part responsible for the significant increases in brain kynurenic acid levels seen under inflammatory conditions | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
D-Aspartate | at pH 7.0 and 25°C | Homo sapiens | |
0.005 | - |
glycine | at pH 7.0 and 25°C | Homo sapiens | |
0.4 | - |
D-serine | at pH 7.0 and 25°C | Homo sapiens | |
1.3 | - |
D-proline | at pH 7.0 and 25°C | Homo sapiens | |
2.1 | - |
D-tryptophan | at pH 7.0 and 25°C | Homo sapiens | |
2.4 | - |
D-phenylalanine | at pH 7.0 and 25°C | Homo sapiens | |
4 | - |
D-alanine | at pH 7.0 and 25°C | Homo sapiens | |
9.9 | - |
D-tyrosine | at pH 7.0 and 25°C | Homo sapiens | |
14.5 | - |
D-Dopa | at pH 7.0 and 25°C | Homo sapiens |