Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target in schizophrenia treatment | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
recombinant expression in rat C6 cells | Mus musculus |
recombinant expression of the enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzoate | - |
Homo sapiens | |
benzoate | - |
Mus musculus | |
benzoate | - |
Sus scrofa | |
risperidone | - |
Homo sapiens | |
risperidone | - |
Mus musculus | |
risperidone | - |
Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Mus musculus | 5777 | - |
peroxisome | - |
Homo sapiens | 5777 | - |
peroxisome | - |
Sus scrofa | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | Mus musculus | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | Homo sapiens | - |
pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | Sus scrofa | - |
pyruvate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
flavoprotein | - |
Mus musculus |
flavoprotein | - |
Homo sapiens |
flavoprotein | - |
Sus scrofa |
Purification (Comment) | Organism |
---|---|
recombinant enzyme by ammonium sulfate fractionation, anion exchange chromatography, and dialysis | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
brain | - |
Sus scrofa | - |
epithelial cell | - |
Sus scrofa | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Sus scrofa | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Sus scrofa | - |
LLC-PK1 cell | a renal epithelial cell line | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | - |
Mus musculus | pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | - |
Homo sapiens | pyruvate + NH3 + H2O2 | - |
? | |
D-alanine + H2O + O2 | - |
Sus scrofa | pyruvate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAO | - |
Mus musculus |
DAO | - |
Homo sapiens |
DAO | - |
Sus scrofa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mus musculus |
25 | - |
assay at | Homo sapiens |
25 | - |
assay at | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
assay at | Mus musculus |
8.3 | - |
assay at | Homo sapiens |
8.3 | - |
assay at | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | flavoenzyme | Mus musculus | |
FAD | flavoenzyme | Homo sapiens | |
FAD | flavoenzyme | Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics with risperidone, in vivo inhibition of cellular DAO activity in LLC-PK1 cells and cytotoxicity, overview | Homo sapiens | |
additional information | - |
additional information | inhibition kinetics with risperidone, in vivo inhibition of cellular DAO activity in LLC-PK1 cells and cytotoxicity, overview | Sus scrofa |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the development of schizophrenia, mechanism, overview | Homo sapiens |