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Literature summary for 1.4.3.3 extracted from

  • Dixon, M.; Kleppe, K.
    D-Amino acid oxidase II. specificity, competitive inhibition and reaction sequence (1965), Biochim. Biophys. Acta, 96, 368-382.
No PubMed abstract available
Search for more literature for 1.4.3.3

Inhibitors

Inhibitors Comment Organism Structure
2-Hydroxy acids
-
 Sus scrofa
2-oxo acids
-
 Sus scrofa
2-oxobutyrate D-alanine oxidation Sus scrofa
aniline slight, D-alanine oxidation Sus scrofa
D-2-Hydroxy-3-methylvalerate D-alanine oxidation Sus scrofa
D-lactate slight, D-alanine oxidation Sus scrofa
DL-2-hydroxybutyrate D-alanine oxidation Sus scrofa
DL-2-Hydroxyoctanoate D-alanine oxidation Sus scrofa
Glycyl-DL-norvaline slight, D-alanine oxidation Sus scrofa
glycyl-DL-phenylalanine slight, D-alanine oxidation Sus scrofa
Glycyl-DL-tryptophan slight, D-alanine oxidation Sus scrofa
Glycyl-DL-valine slight, D-alanine oxidation Sus scrofa
Histidyl-histidine slight, D-alanine oxidation Sus scrofa
L-leucine D-alanine oxidation Sus scrofa
L-methionine D-alanine oxidation Sus scrofa
L-norvaline D-alanine oxidation Sus scrofa
Pyrrolidine slight, D-alanine oxidation Sus scrofa
pyruvate slight, D-alanine oxidation Sus scrofa
Straight-chain fatty acids
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
 2,6-dichlorophenolindophenol with D-alanine Sus scrofa
0.063
-
 D-Norvaline
-
 Sus scrofa
0.067
-
 methylene blue with D-alanine Sus scrofa
0.18
-
 O2 with D-alanine Sus scrofa
0.4
-
 D-norleucine
-
 Sus scrofa
0.46
-
 D-2-aminobutyrate
-
 Sus scrofa
0.83
-
 D-methionine
-
 Sus scrofa
1.4
-
 D-valine
-
 Sus scrofa
1.7
-
 D-proline
-
 Sus scrofa
1.8
-
 D-alanine
-
 Sus scrofa
1.99
-
 thiazolidine-2-carboxylate
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-2-aminobutyrate + H2O + O2 Sus scrofa
-
 2-oxobutyrate + NH3 + H2O2
-
 ?
D-alanine + H2O + O2 Sus scrofa
-
 pyruvic acid + NH3 + H2O2
-
 ?
D-histidine + H2O + O2 Sus scrofa
-
 3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
 ?
D-methionine + H2O + O2 Sus scrofa
-
 4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
 ?
D-norleucine + H2O + O2 Sus scrofa
-
 2-oxohexanoate + NH3 + H2O2
-
 ?
D-norvaline + H2O + O2 Sus scrofa
-
 2-oxopentanoate + NH3 + H2O2
-
 ?
D-ornithine + H2O + O2 Sus scrofa
-
 5-amino-2-oxopentanoate + NH3 + H2O2
-
 ?
D-proline + H2O + O2 Sus scrofa
-
 2-oxopentanoic acid + NH3 + H2O2
-
 ?
D-valine + H2O + O2 Sus scrofa
-
 alpha-ketoisovaleric acid + NH3 + H2O2
-
 ?
thiazolidine-2-carboxylic acid + H2O + O2 Sus scrofa
-
 ? + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-2-aminobutyrate + H2O + O2
-
 Sus scrofa 2-oxobutyrate + NH3 + H2O2
-
 ?
D-alanine + 2,6-dichlorophenolindophenol + H2O
-
 Sus scrofa pyruvate + reduced 2,6-dichlorophenolindophenol + H2O2
-
 r
D-alanine + H2O + O2
-
 Sus scrofa pyruvic acid + NH3 + H2O2
-
 ?
D-alanine + oxidized methylene blue + H2O
-
 Sus scrofa pyruvate + reduced methylene blue + H2O2
-
 r
D-histidine + H2O + O2
-
 Sus scrofa 3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
 ?
D-methionine + H2O + O2
-
 Sus scrofa 4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
 ?
D-norleucine + H2O + O2
-
 Sus scrofa 2-oxohexanoate + NH3 + H2O2
-
 ?
D-norvaline + H2O + O2
-
 Sus scrofa 2-oxopentanoate + NH3 + H2O2
-
 ?
D-ornithine + H2O + O2
-
 Sus scrofa 5-amino-2-oxopentanoate + NH3 + H2O2
-
 ?
D-proline + H2O + O2
-
 Sus scrofa 2-oxopentanoic acid + NH3 + H2O2
-
 ?
D-valine + H2O + O2
-
 Sus scrofa alpha-ketoisovaleric acid + NH3 + H2O2
-
 ?
thiazolidine-2-carboxylic acid + H2O + O2
-
 Sus scrofa ? + NH3 + H2O2
-
 ?