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Literature summary for 1.4.3.22 extracted from
- Correlation of active site metal content in human diamine oxidase with trihydroxyphenylalanine quinone cofactor biogenesis (2010), Biochemistry, 49, 8316-8324.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Drosophila melanogaster Schneider-2 cells | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with aminoguanidine, hanging drop vapor diffusion method, using 0.1M bis-Tris propane (pH 7.5), 20% (w/v) PEG3350, and 0.2 M sodium sulfate at 20°C | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aminoguanidine | potent, irreversible inhibitor | Homo sapiens |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | the metal site is occupied approximately 75% by copper | Homo sapiens | |
| Zn2+ | the metal site is occupied approximately 25% by zinc | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| histamine + H2O + O2 | Homo sapiens | - |
(imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P19801 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,4-diaminobutane + H2O + O2 | - |
Homo sapiens | 4-aminobutanal + NH3 + H2O2 | - |
? | |
| histamine + H2O + O2 | - |
Homo sapiens | (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | x-ray crystallography | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DAO | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 2,4,5-trihydroxyphenylalanine quinone | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000153 | - |
in 100 mM potassium phosphate buffer (pH 7.2), at 37°C | Homo sapiens | aminoguanidine | |
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Release 2023.1 (January 2023)
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