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Literature summary for 1.4.3.22 extracted from

  • Bertini, V.; Buffoni, F.; Ignesti, G.; Picci, N.; Trombino, S.; Iemma, F.; Alfei, S.; Pocci, M.; Lucchesini, F.; De Munno, A.
    Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases (2005), J. Med. Chem., 48, 664-670.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
Sus scrofa
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
Sus scrofa
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
Sus scrofa
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
Sus scrofa
2-ethylaminobenzylamine dihydrochloride
-
Sus scrofa
2-methylaminobenzylamine dihydrochloride
-
Sus scrofa
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
Sus scrofa
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
Sus scrofa
3-amino-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Sus scrofa
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Sus scrofa
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Sus scrofa
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
Sus scrofa
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
Sus scrofa
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
3-methylamino-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-bis(1-methylethyl)pyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
additional information alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
4-aminomethylpyridine dihydrochloride
-
Sus scrofa
0.557
-
benzylamine
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa Q9TRC7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminomethylpyridine dihydrochloride + H2O + O2 8% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases Sus scrofa ?
-
?
benzylamine + H2O + O2
-
Sus scrofa benzaldehyde + NH3 + H2O2
-
?
putrescine + H2O + O2
-
Sus scrofa ?
-
?

Synonyms

Synonyms Comment Organism
DAO
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
above 1.0 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride, 4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride, 1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride, 1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride and above 0.1 mM for 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate, 2-methylaminobenzylamine dihydrochloride, and 2-ethylaminobenzylamine dihydrochloride Sus scrofa additional information
0.000016
-
-
Sus scrofa 3-methylamino-4-aminomethylpyridine dihydrochloride
0.00003
-
-
Sus scrofa 3-amino-4-aminomethylpyridine dihydrochloride
0.00005
-
-
Sus scrofa 3-ethylamino-4-aminomethylpyridine dihydrochloride
0.000061
-
-
Sus scrofa 4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
0.00012
-
-
Sus scrofa 4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
0.001
-
-
Sus scrofa 4-(aminomethyl)-N,N'-bis(1-methylethyl)pyridine-3,5-diamine dihydrochloride
0.0025
-
-
Sus scrofa 4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
0.01
-
-
Sus scrofa 4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
0.016
-
-
Sus scrofa 3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
0.016
-
-
Sus scrofa 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.018
-
-
Sus scrofa 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.019
-
-
Sus scrofa 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
0.05
-
-
Sus scrofa 3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.05
-
-
Sus scrofa 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
1
-
-
Sus scrofa 1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride