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Literature summary for 1.4.3.21 extracted from

  • Pintus, F.; Spano, D.; Floris, G.; Medda, R.
    Euphorbia characias latex amine oxidase and peroxidase: interacting enzymes? (2013), Protein J., 32, 435-441.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
nitric oxide irreversible inhibitor Euphorbia characias
tyramine irreversible inhibitor Euphorbia characias

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ the enzyme contains one non-blue copper type 2 ion as an inorganic cofactor Euphorbia characias

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74000
-
2 * 74000, calculated from amino acid sequence Euphorbia characias

Organism

Organism UniProt Comment Textmining
Euphorbia characias Q9SW90
-
-

Source Tissue

Source Tissue Comment Organism Textmining
latex
-
Euphorbia characias
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme oxidizes arginine to ammonia, urea, hydrogen peroxide and glutamate-5-semialdehyde which spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid Euphorbia characias ?
-
?
ornithine + H2O + O2 ornithine can be transformed in glutamate-5-semialdehyde spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid Euphorbia characias ?
-
?
putrescine + H2O + O2 putrescine can be oxidatively deaminated by the enzyme to corresponding aldehyde that spontaneously cyclizes yielding DELTA1-pyrroline Euphorbia characias ?
-
?
spermidine + H2O + O2 good substrate. The oxidation of spermidine yields to the liberation of ammonia, hydrogen peroxide and the corresponding aldehyde that spontaneously cyclizes yielding first 1-(3-aminopropyl)pyrroliniun and, thereafter, 1,5-diazobicyclononane Euphorbia characias ? + NH3 + H2O2
-
?
spermine + H2O + O2 good substrate Euphorbia characias ? + NH3 + H2O2
-
?
tyramine + H2O + O2 during this reaction, an irreversible inactivation of the enzyme occurs Euphorbia characias 4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 74000, calculated from amino acid sequence Euphorbia characias

Synonyms

Synonyms Comment Organism
copper/quinone containing amine oxidase
-
Euphorbia characias
ELAO
-
Euphorbia characias

Cofactor

Cofactor Comment Organism Structure
2,4,5-trihydroxyphenylalanine quinone
-
Euphorbia characias