Literature summary for 1.4.3.21 extracted from

Gokturk, C.; Sugimoto, H.; Blomgren, B.; Roomans, G.M.; Forsberg-Nilsson, K.; Oreland, L.; Sjoquist, M.
Macrovascular changes in mice overexpressing human semicarbazide-sensitive amine oxidase in smooth muscle cells (2007), Am. J. Hypertens., 20, 743-750.

Cloned(Commentary)

Cloned (Comment)	Organism
mice overexpressing human semicarbazide-sensitive amine oxidase in smooth muscle cells. No differences in elastin quantity or lung capacity could be observed between transgenic or nontransgenic littermates. Pulse pressure is higher in transgenic mice, and aorta shows elastin fibers parallel with the aorta wall (i. e., straight fibers instead of folded compared with control mice). No difference in the response to adrenaline or sodium chloride is observed between the transgenic and control mice. The control mice have a clear decrease in blood pressure with a longer duration as a response to injection of a nitric oxide donor, sodium nitroprusside, compared with transgenic mice where only a minor response is observed. The SSAO activity in serum of control mice is elevated in response to injection of the NO donor, but not in response to a ganglion blocker	Homo sapiens

Cloned (Comment)

Organism

mice overexpressing human semicarbazide-sensitive amine oxidase in smooth muscle cells. No differences in elastin quantity or lung capacity could be observed between transgenic or nontransgenic littermates. Pulse pressure is higher in transgenic mice, and aorta shows elastin fibers parallel with the aorta wall (i. e., straight fibers instead of folded compared with control mice). No difference in the response to adrenaline or sodium chloride is observed between the transgenic and control mice. The control mice have a clear decrease in blood pressure with a longer duration as a response to injection of a nitric oxide donor, sodium nitroprusside, compared with transgenic mice where only a minor response is observed. The SSAO activity in serum of control mice is elevated in response to injection of the NO donor, but not in response to a ganglion blocker

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	physiologic role for SSAO in elastin maturation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzylamine + H2O + O2	-	Homo sapiens	benzaldehyde + NH3 + H2O2	-	?
additional information	physiologic role for SSAO in elastin maturation	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
semicarbazide-sensitive amine oxidase	-	Homo sapiens
SSAO	-	Homo sapiens