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Literature summary for 1.4.3.2 extracted from

  • Ande, S.R.; Fussi, H.; Knauer, H.; Murkovic, M.; Ghisla, S.; Froehlich, K.U.; Macheroux, P.
    Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma (2008), Yeast, 25, 349-357.
    View publication on PubMed

Application

Application Comment Organism
additional information LAAO causes cell death by induction of apoptosis in yeast. Lower concentrations of hydrogen peroxide accompanied by leucine deficiency may have a role in enhancing cell death in leucine auxotrophic yeast strain. LAAO interacts with the cell surface of yeast. Depletion of leucine from the medium by LAAO and the interaction of LAAO with yeast cells are shown to be the major factors responsible for cell demise in the presence of catalase Calloselasma rhodostoma

Inhibitors

Inhibitors Comment Organism Structure
additional information catalase (1.5 micromol) at various concentrations of leucine does not completely inhibit cell death caused by LAAO (1.2 micromol) in leucine auxotrophic strain Calloselasma rhodostoma

Organism

Organism UniProt Comment Textmining
Calloselasma rhodostoma
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Calloselasma rhodostoma
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine + H2O + O2
-
Calloselasma rhodostoma 4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
LAAO
-
Calloselasma rhodostoma