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Literature summary for 1.4.3.2 extracted from

  • Franca, S.C.; Kashima, S.; Roberto, P.G.; Marins, M.; Ticli, F.K.; Pereira, J.O.; Astolfi-Filho, S.; Stabeli, R.G.; Magro, A.J.; Fontes, M.R.; Sampaio, S.V.; Soares, A.M.
    Molecular approaches for structural characterization of Bothrops L-amino acid oxidases with antiprotozoal activity: cDNA cloning, comparative sequence analysis, and molecular modeling (2007), Biochem. Biophys. Res. Commun., 355, 302-306.
    View publication on PubMed

Application

Application Comment Organism
drug development purified LAAO-I exhibits antiprotozoal activities which are demonstrated to be hydrogen-peroxide mediated. Exposure of promastigotes of Leishmania sp. results in dose-dependent parasite killing. LAAOs are interesting multifunctional enzymes, not only for a better understanding of the ophidian envenomation mechanism, but also due to their biotechnological potential as model for therapeutic agents Bothrops moojeni
drug development purified LAAO-I exhibits antiprotozoal activities which are demonstrated to be hydrogen-peroxide mediated. Exposure of promastigotes of Leishmania sp. results in dose-dependent parasite killing. LAAOs are interesting multifunctional enzymes, not only for a better understanding of the ophidian envenomation mechanism, but also due to their biotechnological potential as model for therapeutic agents Bothrops jararacussu

Inhibitors

Inhibitors Comment Organism Structure
additional information catalase inhibits dose-dependent parasite killing Bothrops jararacussu
additional information catalase inhibits dose-dependent parasite killing Bothrops moojeni

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53780
-
sequence analysis Bothrops moojeni
54760
-
sequence analysis Bothrops jararacussu

Organism

Organism UniProt Comment Textmining
Bothrops jararacussu Q6TGQ9
-
-
Bothrops moojeni Q6TGQ8
-
-

Purification (Commentary)

Purification (Comment) Organism
by molecular exclusion, ion exchange and hydrophobic chromatography Bothrops moojeni
by molecular exclusion, ion exchange and hydrophobic chromatography Bothrops jararacussu

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Bothrops moojeni
-
venom
-
Bothrops jararacussu
-
venom gland
-
Bothrops moojeni
-
venom gland
-
Bothrops jararacussu
-

Synonyms

Synonyms Comment Organism
LAAO-I
-
Bothrops moojeni
LAAO-I
-
Bothrops jararacussu

Cofactor

Cofactor Comment Organism Structure
FAD
-
Bothrops moojeni
FAD
-
Bothrops jararacussu

pI Value

Organism Comment pI Value Maximum pI Value
Bothrops jararacussu estimated
-
5.63
Bothrops moojeni estimated
-
5.8