Application | Comment | Organism |
---|---|---|
drug development | purified LAAO-I exhibits antiprotozoal activities which are demonstrated to be hydrogen-peroxide mediated. Exposure of promastigotes of Leishmania sp. results in dose-dependent parasite killing. LAAOs are interesting multifunctional enzymes, not only for a better understanding of the ophidian envenomation mechanism, but also due to their biotechnological potential as model for therapeutic agents | Bothrops moojeni |
drug development | purified LAAO-I exhibits antiprotozoal activities which are demonstrated to be hydrogen-peroxide mediated. Exposure of promastigotes of Leishmania sp. results in dose-dependent parasite killing. LAAOs are interesting multifunctional enzymes, not only for a better understanding of the ophidian envenomation mechanism, but also due to their biotechnological potential as model for therapeutic agents | Bothrops jararacussu |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | catalase inhibits dose-dependent parasite killing | Bothrops jararacussu | |
additional information | catalase inhibits dose-dependent parasite killing | Bothrops moojeni |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53780 | - |
sequence analysis | Bothrops moojeni |
54760 | - |
sequence analysis | Bothrops jararacussu |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bothrops jararacussu | Q6TGQ9 | - |
- |
Bothrops moojeni | Q6TGQ8 | - |
- |
Purification (Comment) | Organism |
---|---|
by molecular exclusion, ion exchange and hydrophobic chromatography | Bothrops moojeni |
by molecular exclusion, ion exchange and hydrophobic chromatography | Bothrops jararacussu |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Bothrops moojeni | - |
venom | - |
Bothrops jararacussu | - |
venom gland | - |
Bothrops moojeni | - |
venom gland | - |
Bothrops jararacussu | - |
Synonyms | Comment | Organism |
---|---|---|
LAAO-I | - |
Bothrops moojeni |
LAAO-I | - |
Bothrops jararacussu |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Bothrops moojeni | |
FAD | - |
Bothrops jararacussu |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Bothrops jararacussu | estimated | - |
5.63 |
Bothrops moojeni | estimated | - |
5.8 |