Literature summary for 1.4.3.13 extracted from

Ma, L.; Huang, C.; Wang, X.J.; Xin, D.E.; Wang, L.S.; Zou, Q.C.; Zhang, Y.S.; Tan, M.D.; Wang, Y.M.; Zhao, T.C.; Chatterjee, D.; Altura, R.A.; Wang, C.; Xu, Y.S.; Yang, J.H.; Fan, Y.S.; Han, B.H.; Si, J.; Zhang, X.; Cheng, J.; Chang, Z.; Chin, Y.E.
Lysyl oxidase 3 is a dual-specificity enzyme involved in stat3 deacetylation and deacetylimination modulation (2017), Mol. Cell, 65, 296-309 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Mus musculus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
peptide acK685 + O2 + H2O	-	Mus musculus	? + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
LOX-like 3	-	Mus musculus
Loxl3	-	Mus musculus
lysyl oxidase 3	-	Mus musculus

General Information

General Information	Comment	Organism
metabolism	by deacetylating and deacetyliminating Stat3 on multiple acetyl-lysine sites in nuclei, the enzyme regulates Stat3 dimerization and transcriptional activity. Furthermore, CD4+ T cell differentiation in inflammatory responses is regulated by the enzyme-Stat3 signaling pathway	Mus musculus
physiological function	the enzyme restricts Stat3-dependent cell proliferation and immune cell differentiation and inflammatory response	Mus musculus

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Release 2023.1 (January 2023)