Cloned (Comment) | Organism |
---|---|
real-time quantitative PCR enzyme expression analysis in wild-type and mutant mice | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutations of the Lox or LoxL1 genes result in a poorly formed vessel wall that is prone to breakdown and aneurysm | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
genes Lox or LoxL1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
smooth muscle | neural crest- and mesoderm-derived smooth muscle | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Mus musculus |
lysyl oxidase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | lineage-specific mutation of the type II TGFbeta receptor gene, Tgfbetar2, in both neural crest- and mesoderm-derived vascular smooth muscle precursors leads to absence of TGFbeta receptor function and reduced lysyl oxidase expression. The result is a poorly organized vascular elastic matrix in late-stage embryos, which is prone to dilation and aneurysm, due to a failure to initiate formation of the elastic matrix, rather than a failure to maintain a preexisting matrix, phenotype of Wnt1Cre/Tgfbr2 mutant embryos, overview | down |
Mus musculus | enzyme expression is induced by TGFbeta treatment in smooth muscle cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | lysyl oxidases play a critical role in matrix assembly by crosslinking elastin and collagen monomers into fibers | Mus musculus |