Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Pelophylax lessonae | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-aspartate + H2O + O2 | Pelophylax lessonae | - |
oxaloacetate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pelophylax lessonae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Pelophylax lessonae | - |
heart | - |
Pelophylax lessonae | - |
kidney | - |
Pelophylax lessonae | - |
liver | - |
Pelophylax lessonae | - |
testis | - |
Pelophylax lessonae | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-aspartate + H2O + O2 | - |
Pelophylax lessonae | oxaloacetate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-AspO | - |
Pelophylax lessonae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Pelophylax lessonae |
Organism | Comment | Expression |
---|---|---|
Pelophylax lessonae | chronic D-Asp treatment leads to upregulation of D-AspO expression in all tissues, along with up- or downregulation of superoxide dismutase 1 and caspase 3 depending on the tissues, overview. D-Asp treated kidney showed the highest D-AspO activity | up |
General Information | Comment | Organism |
---|---|---|
metabolism | in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration, exaggerated D-Asp concentrations activate SOD1 as cytoprotective mechanism in the kidney, whereas, in the brain and in the heart, where the antioxidant action of SOD1 is limited, caspase 3 is activated, overview | Pelophylax lessonae |
physiological function | in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration. Induction of oxidative stress following D-Asp exposure is primarily related to its metabolism by inducible D-AspO | Pelophylax lessonae |