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Literature summary for 1.4.1.B4 extracted from

  • Hanfrey, C.C.; Pearson, B.M.; Hazeldine, S.; Lee, J.; Gaskin, D.J.; Woster, P.M.; Phillips, M.A.; Michael, A.J.
    Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota (2011), J. Biol. Chem., 286, 43301-43312.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.1.B4

Protein Variants

Protein Variants Comment Organism
additional information deletion of the gene encoding carboxynorspermidine dehydrogenase. The CASDH gene deletion strain grows normally Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+ Campylobacter jejuni
-
 carboxynorspermidine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni A0A1J6U6V7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+
-
 Campylobacter jejuni carboxynorspermidine + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CANSDH
-
 Campylobacter jejuni

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Campylobacter jejuni

General Information

General Information Comment Organism
evolution the enzyme is found in diverse bacterial phyla, overview. orthologues encoding carboxyspermidine dehydrogenase and carboxyspermidine decarboxylase are found clustered with an array of diverse putrescine biosynthetic genes in different bacterial genomes, consistent with a role in spermidine, rather than sym-norspermidine biosynthesis Campylobacter jejuni
malfunction the CASDH gene deletion strain grows normally Campylobacter jejuni