Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell line | BE(2)C neuroblastoma cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
glutamate dehydrogenase | - |
Homo sapiens |
hGDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | cofactor specificity not mentioned | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | to test the effect of decreased hGDH expression, small interfering hGDH RNAs are expressed intracellularly in BE(2)C human neuroblastoma cells. hGDH mRNA knockdown is confirmed by immunoblotting and RT-PCR. TUNEL and DNA fragmentation assays 48 h after transfection reveal that inhibition of hGDH expression induces cellular apoptosis and activates phospho-ERK1/2 (phospho-extracellular-signal-regulated kinase 1/2) | Homo sapiens |