Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | 120.88% activity in the presence of 0.25 mM ATP | Rattus norvegicus | |
leucine | with 10 mM the activity increases by 1.55fold after 240 min and by 1.24fold when the enzyme is preincubated with methylglyoxal | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Glyoxal | 67% inhibition at 1 mM | Rattus norvegicus | |
GTP | 8.23% activity in the presence of 0.01 mM ATP | Rattus norvegicus | |
methylglyoxal | with 1 mM methylglyoxal, GDH activity significantly decreases at 30 min of incubation, and markedly drops by 37% within 5 h compared to control | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | - |
Rattus norvegicus | 5759 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
61400 | - |
gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P10860 | precursor | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate + H2O + NAD+ | - |
Rattus norvegicus | 2-oxoglutarate + NH3 + NADH + H+ | - |
? | |
L-glutamate + H2O + NADP+ | - |
Rattus norvegicus | 2-oxoglutarate + NH3 + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GDH | - |
Rattus norvegicus |
glutamate dehydrogenase 1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | utilizes NAD+ for nitrogen liberation | Rattus norvegicus | |
NADP+ | utilizes NADP+ for nitrogen incorporation | Rattus norvegicus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Rattus norvegicus | isoelectric focusing | - |
8.05 |