Literature summary for 1.4.1.2 extracted from

Mailloux, R.J.; Singh, R.; Brewer, G.; Auger, C.; Lemire, J.; Appanna, V.D.
alpha-Ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescens (2009), J. Bacteriol., 191, 3804-3810.

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Protein Variants

Protein Variants	Comment	Organism
molecular biology	alpha-ketoglutarate dehydrogenase and GDH play a critical role in modulating alpha-ketoglutarate homeostasis	Pseudomonas fluorescens

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas fluorescens	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	GDH activity is markedly increased in Pseudomonas fluorescens cultures exposed to menadione-containing media containing Arg, Glu and Pro. When NH4+ is utilized as the nitrogen source, both alpha-ketoglutarate dehydrogenase and GDH levels are diminished. These enzymatic profiles are reversed when control cells are incubated in menadione media	Pseudomonas fluorescens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamate + H2O + NAD+	-	Pseudomonas fluorescens	2-oxoglutarate + NH3 + NADH	-	?

Synonyms

Synonyms	Comment	Organism
glutamate dehydrogenase	-	Pseudomonas fluorescens

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Release 2023.1 (January 2023)