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Literature summary for 1.4.1.14 extracted from

  • Vanoni, M.A.; Curti, B.
    Glutamate synthase: A complex iron-sulfur flavoprotein (1999), Cell. Mol. Life Sci., 55, 617-638.
    View publication on PubMed
Search for more literature for 1.4.1.14

Cloned(Commentary)

Cloned (Comment) Organism
gene encoding NADH-GltS is cloned, N-terminal three quarters of the gene product is similar to the bacterial alpha subunit from NADPH-GltS Saccharomyces cerevisiae
gene encoding NADH-GltS is cloned, N-terminal three quarters of the gene product is similar to the bacterial alpha subunit from NADPH-GltS Medicago sativa
open reading frames encoding proteins similar to NADH-GltS are found during sequencing of genome Caenorhabditis elegans
open reading frames encoding proteins similar to NADH-GltS are found during sequencing of genome Plasmodium falciparum

Metals/Ions

Metals/Ions Comment Organism Structure
3Fe-4S-center iron-sulfur flavoprotein Saccharomyces cerevisiae
3Fe-4S-center iron-sulfur flavoprotein Medicago sativa

Organism

Organism UniProt Comment Textmining
Bombyx mori
-
-
-
Caenorhabditis elegans
-
 NADH-GltS or similar enzyme
-
Medicago sativa
-
-
-
Plasmodium falciparum
-
 NADH-GltS or similar enzyme
-
Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme is synthesized as proprotein with a N-terminal propeptide region Saccharomyces cerevisiae
proteolytic modification enzyme is synthesized as proprotein with a N-terminal propeptide region Caenorhabditis elegans
proteolytic modification enzyme is synthesized as proprotein with a N-terminal propeptide region Medicago sativa
proteolytic modification enzyme is synthesized as proprotein with a N-terminal propeptide region Plasmodium falciparum

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae
-
 Medicago sativa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + 2-oxoglutarate + NADH
-
 Saccharomyces cerevisiae L-glutamate + NAD+
-
 ?
L-glutamine + 2-oxoglutarate + NADH
-
 Bombyx mori L-glutamate + NAD+
-
 ?
L-glutamine + 2-oxoglutarate + NADH
-
 Medicago sativa L-glutamate + NAD+
-
 ?

Cofactor

Cofactor Comment Organism Structure
flavin iron-sulfur flavoprotein Saccharomyces cerevisiae
flavin iron-sulfur flavoprotein Medicago sativa
NADH
-
 Saccharomyces cerevisiae
NADH
-
 Bombyx mori
NADH
-
 Medicago sativa