Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-adenylic acid | competitive inhibitor of the forward reaction with NADPH as the varied substrate, uncompetitive inhibitor with alpha-ketoglutarate or L-glutamine | Escherichia coli | |
L-glutamate | competitive inhibitor of the forward reaction with L-glutamine as the varied substrate, noncompetitive inhibitor with alpha-ketoglutarate as the varied substrate | Escherichia coli | |
L-methionine sulfone | competitive inhibitor vs. L-glutamine, noncompetitive inhibitor vs. alpha-ketoglutarate and uncompetitive vs. NADPH | Escherichia coli | |
NADP+ | competitive vs. NADPH and noncompetitive vs. L-glutamine | Escherichia coli | |
O-carbamoylserine | competitive inhibitor vs. L-glutamine | Escherichia coli | |
oxalylglycine | competitive inhibitor vs. alpha-ketoglutarate, noncompetitive inhibitor vs. L-glutamine and uncompetitive vs. NADPH | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
NADPH | in the presence of 1 mM alpha-ketoglutarate and 5 mM L-glutamine | Escherichia coli | |
0.0047 | - |
alpha-ketoglutarate | in the presence of 0.04 mM NADPH and 5 mM L-glutamine | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+ | kinetic mechanism | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + 2-oxoglutarate + NADPH + H+ | - |
Escherichia coli | L-glutamate + NADP+ | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Escherichia coli |