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Literature summary for 1.4.1.10 extracted from
- Enzyme systems in the Mycobacteria (1962), Biochim. Biophys. Acta, 65, 297-306.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycine | - |
Mycobacterium tuberculosis |  |
| serine | non-competitive | Mycobacterium tuberculosis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Mycobacterium tuberculosis | |
| 0.22 | - |
glyoxylate | - |
Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glyoxylate + NH3 + NADH | Mycobacterium tuberculosis | alternate pathway for formation of glycine in absence of transamination | glycine + H2O + NAD+ | - |
r | |
| glyoxylate + NH3 + NADH | Mycobacterium tuberculosis H37Ra / ATCC 25177 | alternate pathway for formation of glycine in absence of transamination | glycine + H2O + NAD+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
H37Ra strain | - |
| Mycobacterium tuberculosis H37Ra / ATCC 25177 | - |
H37Ra strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| H37Ra strain, partial | Mycobacterium tuberculosis |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 7.25 | - |
- |
Mycobacterium tuberculosis |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -17°C, 72 h, 30-50% loss of activity | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glyoxylate + NH3 + NADH | - |
Mycobacterium tuberculosis | glycine + H2O + NAD+ | - |
r | |
| glyoxylate + NH3 + NADH | alternate pathway for formation of glycine in absence of transamination | Mycobacterium tuberculosis | glycine + H2O + NAD+ | - |
r | |
| glyoxylate + NH3 + NADH | - |
Mycobacterium tuberculosis H37Ra / ATCC 25177 | glycine + H2O + NAD+ | - |
r | |
| glyoxylate + NH3 + NADH | alternate pathway for formation of glycine in absence of transamination | Mycobacterium tuberculosis H37Ra / ATCC 25177 | glycine + H2O + NAD+ | - |
r | |
| additional information | not: acetic acid, oxalic acid | Mycobacterium tuberculosis | ? | - |
? | |
| additional information | not: acetic acid, oxalic acid | Mycobacterium tuberculosis H37Ra / ATCC 25177 | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.4 | - |
assay at | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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