Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
an archaeal alpha-reduced dolichyl phosphate + reduced acceptor | Haloferax volcanii | although HVO_1799 contributes to dolichol phosphate omega-position isoprene reduction, the absence of HVO_1799 does not prevent N-glycosylation in Haloferax volcanii | an archaeal alpha,omega-reduced dolichyl phosphate + acceptor | - |
? | |
an archaeal alpha-reduced dolichyl phosphate + reduced acceptor | Haloferax volcanii DSM 3757 | although HVO_1799 contributes to dolichol phosphate omega-position isoprene reduction, the absence of HVO_1799 does not prevent N-glycosylation in Haloferax volcanii | an archaeal alpha,omega-reduced dolichyl phosphate + acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haloferax volcanii | D4GSC3 | auxotrophic mutant WR536 | - |
Haloferax volcanii DSM 3757 | D4GSC3 | auxotrophic mutant WR536 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
an archaeal alpha-reduced dolichyl phosphate + reduced acceptor | although HVO_1799 contributes to dolichol phosphate omega-position isoprene reduction, the absence of HVO_1799 does not prevent N-glycosylation in Haloferax volcanii | Haloferax volcanii | an archaeal alpha,omega-reduced dolichyl phosphate + acceptor | - |
? | |
an archaeal alpha-reduced dolichyl phosphate + reduced acceptor | the enzyme contributes to dolichol phosphate omega-position isoprene reduction. The actual substrate used by this enzyme has not been experimetally determined | Haloferax volcanii | an archaeal alpha,omega-reduced dolichyl phosphate + acceptor | - |
? | |
an archaeal alpha-reduced dolichyl phosphate + reduced acceptor | although HVO_1799 contributes to dolichol phosphate omega-position isoprene reduction, the absence of HVO_1799 does not prevent N-glycosylation in Haloferax volcanii | Haloferax volcanii DSM 3757 | an archaeal alpha,omega-reduced dolichyl phosphate + acceptor | - |
? | |
an archaeal alpha-reduced dolichyl phosphate + reduced acceptor | the enzyme contributes to dolichol phosphate omega-position isoprene reduction. The actual substrate used by this enzyme has not been experimetally determined | Haloferax volcanii DSM 3757 | an archaeal alpha,omega-reduced dolichyl phosphate + acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DolP omega-isoprene reductase | - |
Haloferax volcanii |
HVO_1799 | locus name | Haloferax volcanii |
General Information | Comment | Organism |
---|---|---|
malfunction | cells deleted of HVO_1799 fail to fully reduce the isoprene chains of membrane phospholipids and glycolipids. The absence of HVO_1799 leads to a loss of saturation of the omega-position isoprene subunit of C55 and C60 dolichol phosphate, with the effect of HVO_1799 deletion being more pronounced with C60 dolichol phosphate than with C55 dolichol phosphate. Glycosylation of dolichol phosphate in the deletion strain occurred preferentially on that version of the lipid saturated at both the alpha- and omega-position isoprene subunits | Haloferax volcanii |