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Literature summary for 1.3.99.5 extracted from

  • Kim, S.; Ma, E.
    Synthesis of pregnane derivatives, their cytotoxicity on LNCap and PC-3 cells, and screening on 5alpha-reductase inhibitory activity (2009), Molecules, 14, 4655-4668.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1,4,6-pregnatriene-3,20-dione
-
Homo sapiens
1alpha,2alpha-epoxy-4,6-pregnadiene-3,20-dione
-
Homo sapiens
20-hydroxyimino-1,4-pregnadiene-3-one
-
Homo sapiens
20-hydroxyimino-4-pregnene-3-one
-
Homo sapiens
20-hydroxyimino-5-oxo-A-nor-3,5-secopregnan-3-oic acid
-
Homo sapiens
3beta-acetoxy-20-hydroxyimino-5-pregnene
-
Homo sapiens
3beta-acetoxy-5-pregnen-20-one
-
Homo sapiens
3beta-hydroxy-20-hydroxyiminopregnenolone
-
Homo sapiens
4-aza-20-hydroxyimino-5-pregnene-3-one an 4-azasteroid Homo sapiens
5alpha,6alpha-epoxy-3beta-acetoxy-20-hydroxyiminopregnane
-
Homo sapiens
5alpha,6alpha-epoxy-3beta-acetoxypregnan-20-one
-
Homo sapiens
5alpha,6alpha-epoxy-3beta-hydroxypregnan-20-one
-
Homo sapiens
5beta,6beta-epoxy-3beta-acetoxy-20-hydroxyiminopregnane
-
Homo sapiens
5beta,6beta-epoxy-3beta-acetoxypregnan-20-one
-
Homo sapiens
finasteride
-
Homo sapiens
additional information synthesis, enzyme inhibitory, and cell cytotoxicity of pregnan compounds, IC50 values for growth inhibition, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydrotestosterone + NADP+ Homo sapiens the enzyme performs conversion of testosterone to dihydrotestosterone testosterone + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
Homo sapiens
-
PC-3 cell
-
Homo sapiens
-
prostate
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrotestosterone + NADP+
-
Homo sapiens testosterone + NADPH + H+
-
r
dihydrotestosterone + NADP+ the enzyme performs conversion of testosterone to dihydrotestosterone Homo sapiens testosterone + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
5alpha-reductase
-
Homo sapiens
5alpha-reductase II
-
Homo sapiens
5AR2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
assay at Homo sapiens