Cloned (Comment) | Organism |
---|---|
Srd5a1 DNA and amino acid sequence determination and analysis, expression of Srd5a2 in HEK-293 cells, real-time quantitative RT-PCR expression analysis with higher mRNA levels for Srd5a1 than for Srd5a2 | Mesocricetus auratus |
Srd5a2 DNA and amino acid sequence determination and analysis, expression of Srd5a2 in HEK-293 cells, real-time quantitative RT-PCR expression analysis with higher mRNA levels for Srd5a1 than for Srd5a2 | Mesocricetus auratus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
testosterone | Srd5a2, pH not specified in the publication, temperature not specified in the publication | Mesocricetus auratus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrotestosterone + NADP+ | Mesocricetus auratus | the isoenzyme efficiently catalyzes the in vitro transformation of testosterone into dihydrotestosterone | testosterone + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | C7T2J7 | Srd5a1 | - |
Mesocricetus auratus | C7T2J8 | Srd5a2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epididymis | Srd5a2 | Mesocricetus auratus | - |
harderian gland | both Srd5a1 and Srd5a2 are expressed without clear differences between males and females | Mesocricetus auratus | - |
liver | Srd5a1 | Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrotestosterone + NADP+ | - |
Mesocricetus auratus | testosterone + NADPH + H+ | - |
r | |
dihydrotestosterone + NADP+ | the isoenzyme efficiently catalyzes the in vitro transformation of testosterone into dihydrotestosterone | Mesocricetus auratus | testosterone + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
SRD5A1 | - |
Mesocricetus auratus |
SRD5A2 | - |
Mesocricetus auratus |
steroid 5alpha-reductase type 1 | - |
Mesocricetus auratus |
steroid 5alpha-reductase type 2 | - |
Mesocricetus auratus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
recombinant Srd5a2 | Mesocricetus auratus |
6.5 | 8 | recombinant Srd5a1 | Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mesocricetus auratus | |
NADPH | - |
Mesocricetus auratus |
Organism | Comment | Expression |
---|---|---|
Mesocricetus auratus | 17beta-estradiol administered to spayed females induces the up-regulation of Srd5a2 mRNA levels | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the isozyme may play a relevant role in modulating androgen signaling in Hardarian glands | Mesocricetus auratus |