Application | Comment | Organism |
---|---|---|
analysis | the mouse pluripotent P-19 cell metabolizes retinol to atRA and thus can be used in a cell-based screen for disruptors of the pathway. The disruption of the pathway is easily detected and quantitated, the P-19 cell provides an in vitro model system for identifying and exploring the mechanism of action of chemicals that interfere with the critical cellular pathway | Mus musculus |
Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR expression analysis | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-13,14-dihydroretinol + acceptor | Mus musculus | - |
all-trans-retinol + reduced acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
P-19 cell | pluripotent embryonal carcinoma cells with high enzyme mRNA level, quantitative real-time PCR expression analysis | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-13,14-dihydroretinol + acceptor | - |
Mus musculus | all-trans-retinol + reduced acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
13,14-dihydroretinol saturase | - |
Mus musculus |
all-trans-13,14-dihydroretinol saturase | - |
Mus musculus |
RetSat | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | effect of retinol on gene expressions in P-19 cells, overview | additional information |
General Information | Comment | Organism |
---|---|---|
metabolism | retinol signaling plays an important role in the establishment and maintenance of cellular phenotype in embryonic and adult vertebrate tissues. all-trans-Retinoic acid functions as the activating ligand for a family of ligand-activated transcription factors, the retinoic acid receptors, which form heterodimers with the retinoid X receptors to regulate gene transcription. Through its activation of the receptors, all-trans-retinoic acid regulates the expression of over 500 protein-coding genes | Mus musculus |
additional information | the mouse pluripotent P-19 cell metabolizes retinol to all-trans-retinoic acid, analysis of expression of enzymes in the cell involved in the pathway, overview | Mus musculus |