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Literature summary for 1.3.99.1 extracted from

  • Armstrong, C.; Staples, J.F.
    The role of succinate dehydrogenase and oxaloacetate in metabolic suppression during hibernation and arousal (2010), J. Comp. Physiol. B, 180, 775-783.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining

General Information

General Information Comment Organism
metabolism SDH inhibition plays a role in metabolic suppression during hibernation and topor, overview. Oxaloacetate reversibly inhibits SDH in torpor, but cannot fully account for the drastic metabolic suppression observed during this hibernation phase. During arousal from the torpor phase of hibernation this suppression is reversed and metabolic rates rise dramatically Ictidomys tridecemlineatus
physiological function SDH catalyzes the oxidation of succinate to fumarate in the matrix of the mitochondrion, donating electrons to ubiquinone that subsequently enter into the electron transport chain Ictidomys tridecemlineatus