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Literature summary for 1.3.8.6 extracted from

  • Rao, K.S.; Albro, M.; Vockley, J.; Frerman, F.E.
    Mechanism-based inactivation of human glutaryl-CoA dehydrogenase by 2-pentynoyl-CoA: rationale for enhanced reactivity (2003), J. Biol. Chem., 278, 26342-26350.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E370D mutant is more sensitive against inactivation by 3-thiaglutaryl-CoA compared to the wild-type enzyme, irreversible inactivation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-pentynoyl-CoA mechanism-based inactivation, inhibition kinetics Homo sapiens
3-thiaglutaryl-CoA non-oxidizable analogue, which competes with 2-pentynoyl-CoA for the binding site Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information reaction and inhibition kinetics Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92947
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutaryl-CoA + 2,6-dichlorophenol indophenol
-
Homo sapiens crotonoyl-CoA + CO2 + reduced 2,6-dichlorophenol indophenol
-
?

Synonyms

Synonyms Comment Organism
GCD
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
flavin
-
Homo sapiens
additional information electron acceptor: 2,6-dichlorophenol indophenol Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0069
-
3-thiaglutaryl-CoA pH 7.6, 25°C Homo sapiens
0.0228
-
3-thiaglutaryl-CoA pH 7.6, 25°C Homo sapiens