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Literature summary for 1.3.8.6 extracted from
- The purification and characterization of glutaryl-coenzyme A dehydrogenase from porcine and human liver (1986), J. Biol. Chem., 261, 4090-4096.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| crotonyl-CoA | - |
Sus scrofa |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0011 | 0.0025 | electron-transfer flavoprotein | - |
Sus scrofa | |
| 0.0012 | 0.01 | glutaryl-CoA | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Sus scrofa | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 47000 | - |
4 * 47000, SDS-PAGE | Sus scrofa |
| 58800 | - |
4 * 58800, SDS-PAGE | Homo sapiens |
| 190500 | - |
gel filtration | Sus scrofa |
| 256000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.3 | - |
- |
Sus scrofa |
| 7.4 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyryl-CoA + acceptor | - |
Sus scrofa | ? + reduced acceptor | - |
? | |
| glutaryl-CoA + acceptor | acceptors: electron-transfer flavoprotein, phenylmethylsulfonyl fluoride, 2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue | Homo sapiens | crotonyl-CoA + CO2 + reduced acceptor | - |
? | |
| glutaryl-CoA + acceptor | acceptors: electron-transfer flavoprotein, phenylmethylsulfonyl fluoride, 2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue | Sus scrofa | crotonyl-CoA + CO2 + reduced acceptor | - |
? | |
| glutaryl-CoA + electron-transfer flavoprotein | - |
Sus scrofa | crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein | - |
r | |
| hexanoyl-CoA + acceptor | - |
Homo sapiens | ? + reduced acceptor | - |
? | |
| hexanoyl-CoA + acceptor | - |
Sus scrofa | ? + reduced acceptor | - |
? | |
| isovaleryl-CoA + acceptor | - |
Sus scrofa | ? + reduced acceptor | - |
? | |
| octanoyl-CoA + acceptor | - |
Sus scrofa | ? + reduced acceptor | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 47000, SDS-PAGE | Sus scrofa |
| tetramer | 4 * 58800, SDS-PAGE | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.45 | - |
glutaryl-CoA | - |
Sus scrofa | |
| 14.3 | - |
electron-transfer flavoprotein | - |
Sus scrofa | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FAD | - |
Sus scrofa | |
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