Literature summary for 1.3.8.1 extracted from

Holm, D.A.; Dagnaes-Hansen, F.; Simonsen, H.; Gregersen, N.; Bolund, L.; Jensen, T.G.; Corydon, T.J.
Expression of short-chain acyl-CoA dehydrogenase (SCAD) proteins in the liver of SCAD deficient mice after hydrodynamic gene transfer (2003), Mol. Genet. Metab., 78, 250-258.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in mouse liver	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G185S	58% of wild-type activity at 41°C after expression in COS-7 cells, mutation may confer susceptibility to accumulation of ethylmalonic acid in affected individuals	Homo sapiens
R147W	45% and 13% of wild-type activity at 37°Cand 41°C, respectively, after expression in COS-7 cells, mutation may confer susceptibility to accumulation of ethylmalonic acid in affected individuals	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
butanoyl-CoA + acceptor	-	Homo sapiens	2-butenoyl-CoA + reduced acceptor	-	r

Synonyms

Synonyms	Comment	Organism
SCAD	-	Homo sapiens

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Release 2023.1 (January 2023)