Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | A77 1726, active metabolite of leflumonide | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
dihydroorotate | cosubstrate ubiquinone-50 | Homo sapiens | |
0.009 | - |
dihydroorotate | cosubstrate decylubiquinone | Homo sapiens | |
0.01 | - |
ubiquinone-50 | cosubstrate dihydroorotate | Homo sapiens | |
0.014 | - |
decylubiquinone | cosubstrate dihydroorotate | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
gel filtration, truncated recombinant protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
truncated recombinant protein | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-dihydroorotate + ubiquinone-50 | - |
Homo sapiens | orotate + ubiquinol-50 | - |
r | |
dihydroorotate + acceptor | acceptor: ubiquinone | Homo sapiens | orotate + reduced acceptor | - |
? | |
L-dihydroorotate + decylubiquinone | - |
Homo sapiens | orotate + reduced decylubiquinone | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | SDS-PAGE, truncated recombinant protein | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | 0.0009 | 2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | competitive to dihydroorotate | Homo sapiens | |
0.001 | - |
2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | non-competitive to decyclubiquinone | Homo sapiens |