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Literature summary for 1.3.5.1 extracted from
- Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain (2007), Naunyn Schmiedebergs Arch. Pharmacol., 376, 127-133.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| aripiprazole | chronic administration of the antipsychotic agent, increases SDH activity in the prefrontal cortex at high doses of 20 mg/kg body weight | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| clozapine | chronic administration of the antipsychotic agent, inhibit SDH activity only in the striatum | Rattus norvegicus | |
| haloperidol | chronic administration of the antipsychotic agent, inhibits SDH activity in the hippocampus and striatum but not in the cerebellum, cortex, and prefrontal cortex | Rattus norvegicus | |
| olanzapine | chronic administration of the antipsychotic agent, inhibits SDH activity only in the cerebellum, but not in the hippocampus, striatum, cortex, and prefrontal cortex | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + oxidized 2,6-dichlorophenolindophenol | in presence of phenazine methosulfate | Rattus norvegicus | fumarate + reduced 2,6-dichlorophenolindophenol | - |
? | |
| succinate + oxidized 2,6-dichlorophenolindophenol | in presence of phenazine methosulfate | Rattus norvegicus | fumarate + reduced 2,6-dichloroindophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | cf. EC 1.3.5.1 | Rattus norvegicus |
| More | cf. EC 1.3.99.1 | Rattus norvegicus |
| SDH | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-dichlorophenolindophenol | in presence of phenazine methosulfate | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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