Literature summary for 1.3.5.1 extracted from

Havekes, B.; Corssmit, E.P.; Jansen, J.C.; van der Mey, A.G.; Vriends, A.H.; Romijn, J.A.
Malignant paragangliomas associated with mutations in the succinate dehydrogenase D gene (2007), J. Clin. Endocrinol. Metab., 92, 1245-1248.

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Protein Variants

Protein Variants	Comment	Organism
D92Y	the naturally occurring mutation of gene SDHD encoding subunit Sdh4p is involved in development of malignant paragangliomas with paraganglioma bone metastases, intrathoracic paraganglioma with lymph node metastases, locally invasive head-and-neck paraganglioma with destruction of the petrosal bone, and locally invasive paraganglioma of the bladder with lymph node metastases, phenotypes, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	subunit mutations are involved in development of malignant paragangliomas	?	-	?
succinate + ubiquinone	Homo sapiens	-	fumarate + ubiquinol	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	subunit mutations are involved in development of malignant paragangliomas	Homo sapiens	?	-	?
succinate + ubiquinone	-	Homo sapiens	fumarate + ubiquinol	-	?

Synonyms

Synonyms	Comment	Organism
SDH	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ubiquinone	-	Homo sapiens

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Release 2023.1 (January 2023)