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Literature summary for 1.3.5.1 extracted from
- A Chinese family with familial paraganglioma syndrome due to succinate dehydrogenase deficiency (2007), Hong Kong Med. J., 13, 151-154.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination of mutated genes SDHB and SDHD from a Chinese family with the familial paraganglioma syndrome, pedigree of the family, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutations of genes SDHb and SDHDencoding subunits of SDH are involved in development of carcinoid tumours and bilateral phaeochromocytoma, phenotype, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + ubiquinone | Homo sapiens | SDH is a key enzyme that catalyses the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Functioning as mitochondrial complex II in the electron transport chain, it transfers electrons extracted from succinate to ubiquinone | fumarate + ubiquinol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + ubiquinone | - |
Homo sapiens | fumarate + ubiquinol | - |
? | |
| succinate + ubiquinone | SDH is a key enzyme that catalyses the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Functioning as mitochondrial complex II in the electron transport chain, it transfers electrons extracted from succinate to ubiquinone | Homo sapiens | fumarate + ubiquinol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mitochondrial complex II | - |
Homo sapiens |
| SDH | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ubiquinone | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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