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Literature summary for 1.3.5.1 extracted from

  • Tushurashvili, P.R.; Gavrikova, E.V.; Ledenev, A.N.; Vinogradov, A.D.
    Studies on the succinate dehydrogenating system. Isolation and properties of the mitochondrial succinate-ubiquinone reductase (1985), Biochim. Biophys. Acta, 809, 145-159.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Thenoyltrifluoroacetone
-
Bos taurus
carboxin Q2-mediated Wurster's blue reduction: 90% inhibition at 0.02 mM, Q0-mediated Wurster's blue reduction: 75% inhibition at 0.02 mM, Q1-mediated Wurster's blue reduction: 88% inhibition at 0.02 mM, Q6-mediated Wurster's blue reduction: 50% inhibition at 0.02 mM Bos taurus
fumarate
-
Bos taurus
malonate
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
ubiquinone-2
-
Bos taurus
0.02
-
succinate
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
succinate dehydrogenase
-

Purification (Commentary)

Purification (Comment) Organism
using urea washing, Triton X-100 extraction, cholate-ammonium sulfate extraction, calcium phosphate gel and ammonium sulfate precipitation Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
28 54 depending on assay temperature Bos taurus

Storage Stability

Storage Stability Organism
liquid N2 or -20°C, pH 6.0, presence of 0.1% Triton X-100 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone
-
Bos taurus fumarate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinol
-
?
succinate + ubiquinone
-
Bos taurus fumarate + ubiquinol
-
?

Subunits

Subunits Comment Organism
tetramer heart, succinate dehydrogenase, SDS-PAGE Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
83.3 150 succinate based on FAD content, dependency on assay temperature Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Bos taurus

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 8 inactivation below pH 5, stable for about 20 h without loss of activity at pH 6.0 in the presence of 0.1% Triton X-100 Bos taurus

Cofactor

Cofactor Comment Organism Structure
cytochrome b
-
Bos taurus
cytochrome b-560
-
Bos taurus
FAD
-
Bos taurus
additional information the enzyme contains acid-labile sulfides Bos taurus
ubiquinone
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00025
-
malonate
-
Bos taurus
0.001
-
carboxin
-
Bos taurus
0.008
-
2-Thenoyltrifluoroacetone
-
Bos taurus
0.04
-
fumarate
-
Bos taurus