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Literature summary for 1.3.3.4 extracted from

  • Corradi, H.R.; Corrigall, A.V.; Boix, E.; Mohan, C.G.; Sturrock, E.D.; Meissner, P.N.; Acharya, K.R.
    Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen (2006), J. Biol. Chem., 281, 38625-38633.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine conserved structural features in relation to a number of South African variegate porphyria-causing mutations in the human enzyme Myxococcus xanthus

Cloned(Commentary)

Cloned (Comment) Organism
pMx-PPO vector transfected into and maintained in Escherichia coli JM109 cells Myxococcus xanthus

Crystallization (Commentary)

Crystallization (Comment) Organism
by the hanging drop vapor diffusion method at 16°C in the dark Myxococcus xanthus

Inhibitors

Inhibitors Comment Organism Structure
acifluorfen is accommodated by the shape of the binding pocket and hold in place by electrostatic and aromatic interactions Myxococcus xanthus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane interaction/orientation Myxococcus xanthus 16020
-

Organism

Organism UniProt Comment Textmining
Myxococcus xanthus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Myxococcus xanthus

Subunits

Subunits Comment Organism
monomer crystallographic studies Myxococcus xanthus

Synonyms

Synonyms Comment Organism
PPOX
-
Myxococcus xanthus
protoporphyrinogen IX oxidase
-
Myxococcus xanthus