Literature summary for 1.3.3.4 extracted from

Arnould, S.; Berthon, J.L.; Hubert, C.; Dias, M.; Cibert, C.; Mornet, R.; Camadro, J.M.
Kinetics of protoporphyrinogen oxidase inhibition by diphenyleneiodonium derivatives (1997), Biochemistry, 36, 10178-10184.

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Inhibitors

Inhibitors	Comment	Organism	Structure
diphenylene iodonium	competitive with respect to oxygen, strongly pH dependent, maximal at pH 8, inhibition by derivatives	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	membrane bound	Saccharomyces cerevisiae	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protoporphyrinogen-IX + 3 O2	Saccharomyces cerevisiae	penultimate step of heme and chlorophyll biosynthesis	protoporphyrin-IX + 3 H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Storage Stability

Storage Stability	Organism
-80°C, 0.1 M phosphate buffer, 1 mM EDTA, 1 mM dithiothreitol, 0.07 mg/ml phenylmethylsulfonyl fluoride, months, no loss of activity	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
protoporphyrinogen-IX + 3 O2	-	Saccharomyces cerevisiae	protoporphyrin-IX + 3 H2O2	-	?
protoporphyrinogen-IX + 3 O2	penultimate step of heme and chlorophyll biosynthesis	Saccharomyces cerevisiae	protoporphyrin-IX + 3 H2O2	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00007	-	diphenylebeiodonium	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)