Activating Compound | Comment | Organism | Structure |
---|---|---|---|
FAD | slight stimulation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FMN | - |
Mus musculus | |
heme | - |
Mus musculus | |
additional information | not inhibited by sulfhydryl reagents | Mus musculus | |
N-ethylmaleimide | no inhibition | Mus musculus | |
N-Methylprotoporphyrin | slight, 11% inhibition at 0.0001 mM | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0056 | - |
protoporphyrinogen-IX | - |
Mus musculus | |
0.09 | - |
Mesoporphyrinogen-IX | - |
Mus musculus | |
0.09 | - |
hematoporphyrinogen-IX | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no stimulation or inhibition by divalent cations | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
gel filtration, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoporphyrinogen-IX + 3 O2 | Mus musculus | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.038 | - |
purified enzyme | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hematoporphyrinogen-IX + 3 O2 | - |
Mus musculus | hematoporphyrin-IX + 3 H2O2 | - |
? | |
mesoporphyrinogen-IX + 3 O2 | - |
Mus musculus | mesoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | - |
Mus musculus | protoporphyrin-IX + 3 H2O2 | - |
? | |
protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Mus musculus | protoporphyrin-IX + 3 H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | gel filtration, SDS-PAGE | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.1 | - |
- |
Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.5 | - |
Mus musculus |