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Literature summary for 1.3.3.4 extracted from

  • Dailey, H.A.; Karr, S.W.
    Purification and characterization of murine protoporphyrinogen oxidase (1987), Biochemistry, 26, 2697-2701.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
FAD slight stimulation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
FMN
-
Mus musculus
heme
-
Mus musculus
additional information not inhibited by sulfhydryl reagents Mus musculus
N-ethylmaleimide no inhibition Mus musculus
N-Methylprotoporphyrin slight, 11% inhibition at 0.0001 mM Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0056
-
protoporphyrinogen-IX
-
Mus musculus
0.09
-
Mesoporphyrinogen-IX
-
Mus musculus
0.09
-
hematoporphyrinogen-IX
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no stimulation or inhibition by divalent cations Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
gel filtration, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrinogen-IX + 3 O2 Mus musculus penultimate step of heme and chlorophyll biosynthesis protoporphyrin-IX + 3 H2O2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.038
-
purified enzyme Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hematoporphyrinogen-IX + 3 O2
-
Mus musculus hematoporphyrin-IX + 3 H2O2
-
?
mesoporphyrinogen-IX + 3 O2
-
Mus musculus mesoporphyrin-IX + 3 H2O2
-
?
protoporphyrinogen-IX + 3 O2
-
Mus musculus protoporphyrin-IX + 3 H2O2
-
?
protoporphyrinogen-IX + 3 O2 penultimate step of heme and chlorophyll biosynthesis Mus musculus protoporphyrin-IX + 3 H2O2
-
?

Subunits

Subunits Comment Organism
monomer gel filtration, SDS-PAGE Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
-
Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5
-
Mus musculus