Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.3.3 extracted from

  • Akagi, R.; Inoue, R.; Muranaka, S.; Tahara, T.; Taketani, S.; Anderson, K.E.; Phillips, J.D.; Sassa, S.
    Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient (2006), Br. J. Haematol., 132, 237-243.
    View publication on PubMed

Application

Application Comment Organism
medicine first patient with porphyria where both CPO and delta-aminolaevulinic acid dehydratase are deficient at the molecular level Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
mature form of wild-type CPOX cloned into pET-22, wild-type and mutant protein expressed in Escherichia coli BL21(DE3)plysS Homo sapiens

Protein Variants

Protein Variants Comment Organism
G279R novel nucleotide transition found, is unstable, and produces ca. 2-5% of activity compared with the wild-type CPO Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P36551 male patient with a typical attack of hepatic porphyria
-

Purification (Commentary)

Purification (Comment) Organism
by Ni2+ affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+
-
Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?

Synonyms

Synonyms Comment Organism
coproporphyrinogen oxidase
-
Homo sapiens
CPO
-
Homo sapiens
CPOX
-
Homo sapiens