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Literature summary for 1.3.3.3 extracted from

  • Cooper, C.L.; Stob, C.M.; Jones, M.A.; Lash, T.D.
    Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: further evidence for the existence of an abnormal pathway for heme biosynthesis (2005), Bioorg. Med. Chem., 13, 6244-6251.
    View publication on PubMed
Search for more literature for 1.3.3.3

Application

Application Comment Organism
medicine abnormal route for heme biosynthesis in humans suffering from porphyria cutanea tarda or related syndromes such as hexachlorobenzene poisoning Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00054
-
 Coproporphyrinogen-III total product Homo sapiens
0.00054
-
 Coproporphyrinogen III pH and temperature not specified in the publication Homo sapiens
0.00055
-
 Coproporphyrinogen-III divinyl as product Homo sapiens
0.00097
-
 Coproporphyrinogen-III monovinyl as product Homo sapiens
0.0013
-
 pentacarboxylate porphyrinogen 5dab monovinyl as product Homo sapiens
0.0013
-
 pentacarboxylate porphyrinogen 5dab total product Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 1 * 37000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen III + O2 Homo sapiens
-
 coproporphyrin III + H2O
-
 ?
protoporphyrinogen IX + O2 Homo sapiens
-
 protoporphyrin IX + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by Ni2+ affinity chromatography Homo sapiens
Ni2+ affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen III + O2
-
 Homo sapiens coproporphyrin III + H2O
-
 ?
coproporphyrinogen-III + O2 + 2 H+
-
 Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
additional information pentacarboxylate porphyrinogens 5abc, 5abd, and 5acd are not metabolized Homo sapiens ?
-
 ?
pentacarboxylate porphyrinogen 5dab + O2 poorer substrate than coproporphyrinogen-III Homo sapiens dehydroisocoproporphyrinogen
-
 ?
protoporphyrinogen IX + O2
-
 Homo sapiens protoporphyrin IX + H2O
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 37000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
copro'gen oxidase
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0033
-
 Coproporphyrinogen-III monovinyl as product Homo sapiens
0.009
-
 pentacarboxylate porphyrinogen 5dab monovinyl as product Homo sapiens
0.009
-
 pentacarboxylate porphyrinogen 5dab total product Homo sapiens
0.0125
-
 Coproporphyrinogen-III divinyl as product Homo sapiens
0.01616
-
 Coproporphyrinogen-III total product Homo sapiens
0.017
-
 Coproporphyrinogen III pH and temperature not specified in the publication Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.5
-
 Coproporphyrinogen III pH and temperature not specified in the publication Homo sapiens