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Literature summary for 1.3.3.3 extracted from

  • Susa, S.; Daimon, M.; Ono, H.; Li, S.; Yoshida, T.; Kato, T.
    Heme inhibits the mitochondrial import of coproporphyrinogen oxidase. Comments (2002), Blood, 100, 4678-4679.
    View publication on PubMed
Search for more literature for 1.3.3.3

Cloned(Commentary)

Cloned (Comment) Organism
in-vitro transcription and translation of the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information heme inhibits the mitochondrial import of the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion human enzyme is imported in isolated rat mitochondria, heme inhibits the mitochondrial import of the enzyme completely at 0.02 mM concentration Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen-III + O2 Homo sapiens enzyme catalyzes the 6th step in heme biosynthesis, heme might be a feed-back regulator of its synthesis by inhibiting the import of th enzyme into mitochondria protoporphyrinogen-IX + CO2 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen-III + O2
-
 Homo sapiens protoporphyrinogen-IX + CO2 + H2O
-
 ?
coproporphyrinogen-III + O2 enzyme catalyzes the 6th step in heme biosynthesis, heme might be a feed-back regulator of its synthesis by inhibiting the import of th enzyme into mitochondria Homo sapiens protoporphyrinogen-IX + CO2 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CPO
-
 Homo sapiens