Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.3.3 extracted from

  • Sorianello, E.M.; Mazzetti, M.B.
    Function and structure of rat hepatic coproporphyrinogen oxidase (2000), Comp. Biochem. Physiol. B, 127, 155-164.
    View publication on PubMed
Search for more literature for 1.3.3.3

Activating Compound

Activating Compound Comment Organism Structure
L-alpha-phosphatidylcholine activation in sonicated mitochondria up to 150% Rattus sp.
phosphatidate activation in sonicated mitochondria up to 150% Rattus sp.
phosphatidyl glycerol activation in intact and sonicated mitochondria up to 135% Rattus sp.
Triton X-100 concentration-dependent activation up to 2.8fold Rattus sp.
Tween 20 concentration-dependent activation up to 152% Rattus sp.

General Stability

General Stability Organism
purified enzyme rather unstable, 2 days Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
diethyl dicarbonate concentration-dependent inhibition, complete inactivation at 50 mM Rattus sp.
KCl 70% inhibition at 1 M Rattus sp.
N-bromosuccinimide concentration-dependent inhibition, complete inactivation at 50 mM Rattus sp.
NaCl 60% inhibition at 1 M Rattus sp.
Phenylglyoxal concentration-dependent inhibition, complete inactivation at 50 mM Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion located within intermembrane space Rattus sp. 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 2 * 38000, SDS-PAGE Rattus sp.
77000
-
 minimum catalytic activity, also aggregation to 154000 kDa catalytic activity, gel filtration Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+ Rattus sp. 6th enzyme in heme biosynthetic pathway protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography techniques Rattus sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.009
-
-
 Rattus sp.

Storage Stability

Storage Stability Organism
-20°C, 30-65% ammonium sulfate precipitate, 2 months Rattus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+ sixths enzyme in heme biosynthetic pathway Rattus sp. protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
coproporphyrinogen-III + O2 + 2 H+ 6th enzyme in heme biosynthetic pathway Rattus sp. protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 38000, SDS-PAGE Rattus sp.

Synonyms

Synonyms Comment Organism
CPGox
-
 Rattus sp.