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Literature summary for 1.3.3.15 extracted from

  • Hobbs, C.; Dailey, H.A.; Shepherd, M.
    The HemQ coprohaem decarboxylase generates reactive oxygen species: implications for the evolution of classical haem biosynthesis (2016), Biochem. J., 473, 3997-4009.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) pLysS cells Staphylococcus aureus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0067
-
Coproporphyrinogen III at pH 8.0 and 37°C Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen III + O2 Staphylococcus aureus
-
coproporphyrin III + H2O
-
?
protoporphyrinogen IX + O2 Staphylococcus aureus
-
protoporphyrin IX + H2O
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cobalt chelate column chromatography Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen III + O2
-
Staphylococcus aureus coproporphyrin III + H2O
-
?
protoporphyrinogen IX + O2
-
Staphylococcus aureus protoporphyrin IX + H2O
-
?

Synonyms

Synonyms Comment Organism
hemY
-
Staphylococcus aureus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.44
-
protoporphyrinogen IX at pH 8.0 and 37°C Staphylococcus aureus
0.46
-
Coproporphyrinogen III at pH 8.0 and 37°C Staphylococcus aureus