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Literature summary for 1.3.1.98 extracted from

  • Gilbert, A.M.; Failli, A.; Shumsky, J.; Yang, Y.; Severin, A.; Singh, G.; Hu, W.; Keeney, D.; Petersen, P.J.; Katz, A.H.
    Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase (2006), J. Med. Chem., 49, 6027-6036.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in strain BL21(DE3) Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide
-
Candida albicans
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide
-
Enterococcus faecalis
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide
-
Escherichia coli
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide
-
Staphylococcus aureus
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide
-
Streptococcus pneumoniae
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide
-
Candida albicans
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide
-
Enterococcus faecalis
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide
-
Escherichia coli
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide
-
Staphylococcus aureus
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide
-
Streptococcus pneumoniae
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione
-
Candida albicans
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione
-
Enterococcus faecalis
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione
-
Escherichia coli
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione
-
Staphylococcus aureus
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione
-
Streptococcus pneumoniae
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide
-
Candida albicans
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide
-
Enterococcus faecalis
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide
-
Escherichia coli
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide
-
Staphylococcus aureus
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide
-
Streptococcus pneumoniae
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Candida albicans
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Enterococcus faecalis
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Escherichia coli
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Staphylococcus aureus
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Streptococcus pneumoniae
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione
-
Candida albicans
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione
-
Enterococcus faecalis
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione
-
Escherichia coli
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione
-
Staphylococcus aureus
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide
-
Candida albicans
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Candida albicans
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Escherichia coli
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one
-
Candida albicans
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one
-
Escherichia coli
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one
-
Candida albicans
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one
-
Escherichia coli
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
-
Candida albicans
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
-
Enterococcus faecalis
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
-
Escherichia coli
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
-
Staphylococcus aureus
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione
-
Streptococcus pneumoniae
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione
-
Candida albicans
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione
-
Enterococcus faecalis
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione
-
Escherichia coli
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione
-
Staphylococcus aureus
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione
-
Streptococcus pneumoniae
1,2-diphenylpyrazolidine-3,5-dione slight inhibition Candida albicans
1,2-diphenylpyrazolidine-3,5-dione slight inhibition Enterococcus faecalis
1,2-diphenylpyrazolidine-3,5-dione slight inhibition Escherichia coli
1,2-diphenylpyrazolidine-3,5-dione slight inhibition Staphylococcus aureus
1,2-diphenylpyrazolidine-3,5-dione slight inhibition Streptococcus pneumoniae
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Candida albicans
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Escherichia coli
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Candida albicans
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Escherichia coli
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Candida albicans
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Enterococcus faecalis
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Escherichia coli
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Staphylococcus aureus
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one
-
Streptococcus pneumoniae
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid
-
Candida albicans
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid
-
Enterococcus faecalis
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid
-
Escherichia coli
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid
-
Staphylococcus aureus
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid
-
Streptococcus pneumoniae
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester
-
Candida albicans
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester
-
Enterococcus faecalis
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester
-
Escherichia coli
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester
-
Staphylococcus aureus
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester
-
Streptococcus pneumoniae
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide
-
Candida albicans
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide
-
Enterococcus faecalis
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide
-
Escherichia coli
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide
-
Staphylococcus aureus
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide
-
Streptococcus pneumoniae
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Candida albicans
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Enterococcus faecalis
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Escherichia coli
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Staphylococcus aureus
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide
-
Streptococcus pneumoniae
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide
-
Candida albicans
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide
-
Enterococcus faecalis
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide
-
Escherichia coli
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide
-
Staphylococcus aureus
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide
-
Streptococcus pneumoniae
additional information maximal inhibition concentration, i.e. MIC, values, overview Candida albicans
additional information maximal inhibition concentration, i.e. MIC, values, overview Enterococcus faecalis
additional information maximal inhibition concentration, i.e. MIC, values, overview Escherichia coli
additional information maximal inhibition concentration, i.e. MIC, values, overview Staphylococcus aureus
additional information maximal inhibition concentration, i.e. MIC, values, overview Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetylenolpyruvylglucosamine + NADPH Staphylococcus aureus
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Escherichia coli
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Enterococcus faecalis
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Streptococcus pneumoniae
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Candida albicans
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Staphylococcus aureus GC 1131
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Escherichia coli GC 4560 imp
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Streptococcus pneumoniae GC 1894
-
UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH Enterococcus faecalis GC 2242
-
UDP-N-acetylmuramic acid + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Enterococcus faecalis
-
-
-
Enterococcus faecalis GC 2242
-
-
-
Escherichia coli
-
-
-
Escherichia coli GC 4560 imp
-
-
-
Staphylococcus aureus
-
-
-
Staphylococcus aureus GC 1131
-
-
-
Streptococcus pneumoniae
-
-
-
Streptococcus pneumoniae GC 1894
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from strain BL21(DE3) by ammonium sulfate fractionation, hydrophobic interaction and ion exchange chromatography to homogeneity Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Staphylococcus aureus UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Escherichia coli UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Enterococcus faecalis UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Streptococcus pneumoniae UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Candida albicans UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Staphylococcus aureus GC 1131 UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Escherichia coli GC 4560 imp UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Streptococcus pneumoniae GC 1894 UDP-N-acetylmuramic acid + NADP+
-
?
UDP-N-acetylenolpyruvylglucosamine + NADPH
-
Enterococcus faecalis GC 2242 UDP-N-acetylmuramic acid + NADP+
-
?

Synonyms

Synonyms Comment Organism
MurB
-
Staphylococcus aureus
MurB
-
Escherichia coli
MurB
-
Enterococcus faecalis
MurB
-
Streptococcus pneumoniae
MurB
-
Candida albicans
UDP-N-acetylenolpyruvyl glucosamine reductase
-
Staphylococcus aureus
UDP-N-acetylenolpyruvyl glucosamine reductase
-
Escherichia coli
UDP-N-acetylenolpyruvyl glucosamine reductase
-
Enterococcus faecalis
UDP-N-acetylenolpyruvyl glucosamine reductase
-
Streptococcus pneumoniae
UDP-N-acetylenolpyruvyl glucosamine reductase
-
Candida albicans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Staphylococcus aureus
8
-
assay at Escherichia coli
8
-
assay at Enterococcus faecalis
8
-
assay at Streptococcus pneumoniae
8
-
assay at Candida albicans

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Staphylococcus aureus
NADPH
-
Escherichia coli
NADPH
-
Enterococcus faecalis
NADPH
-
Streptococcus pneumoniae
NADPH
-
Candida albicans