Cloned (Comment) | Organism |
---|---|
overexpression in strain BL21(DE3) | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide | - |
Candida albicans | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide | - |
Escherichia coli | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3,4-dichlorophenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide | - |
Candida albicans | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide | - |
Enterococcus faecalis | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide | - |
Escherichia coli | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide | - |
Staphylococcus aureus | |
1,2-bis(3,4-dichlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 4-tolylamide | - |
Streptococcus pneumoniae | |
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione | - |
Candida albicans | |
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione | - |
Enterococcus faecalis | |
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione | - |
Escherichia coli | |
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione | - |
Staphylococcus aureus | |
1,2-bis(3,4-dichlorophenyl)pyrazolidine-3,5-dione | - |
Streptococcus pneumoniae | |
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide | - |
Candida albicans | |
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide | - |
Escherichia coli | |
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(3-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxylic acid (4-chlorophenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Candida albicans | |
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Escherichia coli | |
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(3-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione | - |
Candida albicans | |
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione | - |
Enterococcus faecalis | |
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione | - |
Escherichia coli | |
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione | - |
Staphylococcus aureus | |
1,2-bis(3-chlorophenyl)pyrazolidine-3,5-dione | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-3,5-dioxo-N-phenylpyrazolidine-4-carboxamide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-4-(3,4-dichlorobenzoyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-4-cyclohexanecarbonyl-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1-naphthalen-2-ylethyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2-chlorophenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-chlorophenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (3-trifluoromethylphenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-cyanophenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-methoxyphenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-trifluoromethylphenyl)amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2,4-dichlorobenzylamide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 2-chlorobenzylamide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid 3,4-dichlorobenzylamide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid cyclohexylamide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenethylamide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [1-(4-bromophenyl)ethyl]amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid [4(3-(dimethylamino)propylcarbamoyl)-phenyl]amide | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-methoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethoxybenzoyl)-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(4-trifluoromethylbenzoyl)-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-(thiophene-2-carbonyl)-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)-5-hydroxy-4-[2-(4-methoxyphenyl)acetyl]-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Candida albicans | |
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Enterococcus faecalis | |
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Escherichia coli | |
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Staphylococcus aureus | |
1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione | - |
Streptococcus pneumoniae | |
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione | - |
Candida albicans | |
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione | - |
Enterococcus faecalis | |
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione | - |
Escherichia coli | |
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione | - |
Staphylococcus aureus | |
1,2-bis(4-fluorophenyl)pyrazolidine-3,5-dione | - |
Streptococcus pneumoniae | |
1,2-diphenylpyrazolidine-3,5-dione | slight inhibition | Candida albicans | |
1,2-diphenylpyrazolidine-3,5-dione | slight inhibition | Enterococcus faecalis | |
1,2-diphenylpyrazolidine-3,5-dione | slight inhibition | Escherichia coli | |
1,2-diphenylpyrazolidine-3,5-dione | slight inhibition | Staphylococcus aureus | |
1,2-diphenylpyrazolidine-3,5-dione | slight inhibition | Streptococcus pneumoniae | |
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
4-(4-butoxybenzoyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
4-(4-chlorobenzoyl)1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Candida albicans | |
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Enterococcus faecalis | |
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Escherichia coli | |
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Staphylococcus aureus | |
4-(biphenylyl-4-carbonyl)-1,2-bis(4-chlorophenyl)-5-hydroxy-1,2-dihydropyrazol-3-one | - |
Streptococcus pneumoniae | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid | - |
Candida albicans | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid | - |
Enterococcus faecalis | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid | - |
Escherichia coli | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid | - |
Staphylococcus aureus | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid | - |
Streptococcus pneumoniae | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester | - |
Candida albicans | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester | - |
Enterococcus faecalis | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester | - |
Escherichia coli | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester | - |
Staphylococcus aureus | |
4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid ethyl ester | - |
Streptococcus pneumoniae | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide | - |
Candida albicans | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide | - |
Enterococcus faecalis | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide | - |
Escherichia coli | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide | - |
Staphylococcus aureus | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-bromophenyl)amide | - |
Streptococcus pneumoniae | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Candida albicans | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Enterococcus faecalis | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Escherichia coli | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Staphylococcus aureus | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chlorophenyl)amide | - |
Streptococcus pneumoniae | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide | - |
Candida albicans | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide | - |
Enterococcus faecalis | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide | - |
Escherichia coli | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide | - |
Staphylococcus aureus | |
5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide | - |
Streptococcus pneumoniae | |
additional information | maximal inhibition concentration, i.e. MIC, values, overview | Candida albicans | |
additional information | maximal inhibition concentration, i.e. MIC, values, overview | Enterococcus faecalis | |
additional information | maximal inhibition concentration, i.e. MIC, values, overview | Escherichia coli | |
additional information | maximal inhibition concentration, i.e. MIC, values, overview | Staphylococcus aureus | |
additional information | maximal inhibition concentration, i.e. MIC, values, overview | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetylenolpyruvylglucosamine + NADPH | Staphylococcus aureus | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Escherichia coli | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Enterococcus faecalis | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Streptococcus pneumoniae | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Candida albicans | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Staphylococcus aureus GC 1131 | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Escherichia coli GC 4560 imp | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Streptococcus pneumoniae GC 1894 | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | Enterococcus faecalis GC 2242 | - |
UDP-N-acetylmuramic acid + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Enterococcus faecalis | - |
- |
- |
Enterococcus faecalis GC 2242 | - |
- |
- |
Escherichia coli | - |
- |
- |
Escherichia coli GC 4560 imp | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus GC 1131 | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae GC 1894 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from strain BL21(DE3) by ammonium sulfate fractionation, hydrophobic interaction and ion exchange chromatography to homogeneity | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Staphylococcus aureus | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Escherichia coli | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Enterococcus faecalis | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Streptococcus pneumoniae | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Candida albicans | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Staphylococcus aureus GC 1131 | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Escherichia coli GC 4560 imp | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Streptococcus pneumoniae GC 1894 | UDP-N-acetylmuramic acid + NADP+ | - |
? | |
UDP-N-acetylenolpyruvylglucosamine + NADPH | - |
Enterococcus faecalis GC 2242 | UDP-N-acetylmuramic acid + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MurB | - |
Staphylococcus aureus |
MurB | - |
Escherichia coli |
MurB | - |
Enterococcus faecalis |
MurB | - |
Streptococcus pneumoniae |
MurB | - |
Candida albicans |
UDP-N-acetylenolpyruvyl glucosamine reductase | - |
Staphylococcus aureus |
UDP-N-acetylenolpyruvyl glucosamine reductase | - |
Escherichia coli |
UDP-N-acetylenolpyruvyl glucosamine reductase | - |
Enterococcus faecalis |
UDP-N-acetylenolpyruvyl glucosamine reductase | - |
Streptococcus pneumoniae |
UDP-N-acetylenolpyruvyl glucosamine reductase | - |
Candida albicans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Staphylococcus aureus |
8 | - |
assay at | Escherichia coli |
8 | - |
assay at | Enterococcus faecalis |
8 | - |
assay at | Streptococcus pneumoniae |
8 | - |
assay at | Candida albicans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Staphylococcus aureus | |
NADPH | - |
Escherichia coli | |
NADPH | - |
Enterococcus faecalis | |
NADPH | - |
Streptococcus pneumoniae | |
NADPH | - |
Candida albicans |