Literature summary for 1.3.1.92 extracted from

Beyraghdar Kashkooli, A.; van der Krol, A.; Rabe, P.; Dickschat, J.; Bouwmeester, H.
Substrate promiscuity of enzymes from the sesquiterpene biosynthetic pathways from Artemisia annua and Tanacetum parthenium allows for novel combinatorial sesquiterpene production (2019), Metab. Eng., 54, 12-23 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Nicotiana benthamiana	Artemisia annua

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
artemisinic aldehyde + NADPH + H+	Artemisia annua	-	(11R)-dihydroartemisinic aldehyde + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Artemisia annua	C5H429	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3beta-hydroxycostunolide + NADPH + H+	-	Artemisia annua	3beta-hydroxy-dihydroparthenolide + NADP+	-	?
artemisinic aldehyde + NADPH + H+	-	Artemisia annua	(11R)-dihydroartemisinic aldehyde + NADP+	-	?
costunolide + NADPH + H+	-	Artemisia annua	dihydrocostunolide + NADP+	-	?
parthenolide + NADPH + H+	good substrate	Artemisia annua	dihydroparthenolide + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
artemisinic aldehyde DELTA11(13) double bond reductase2	-	Artemisia annua
Dbr2	-	Artemisia annua

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Artemisia annua

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Release 2023.1 (January 2023)