Literature summary for 1.3.1.92 extracted from

Liu, W.; Wang, H.; Chen, Y.; Zhu, S.; Chen, M.; Lan, X.; Chen, G.; Liao, Z.
Cold stress improves the production of artemisinin depending on the increase in endogenous jasmonate (2016), Biotechnol. Appl. Biochem., 64, 305-314 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene DBR2, quantitative real-time PCR expression analysis	Artemisia annua

Organism

Organism	UniProt	Comment	Textmining
Artemisia annua	C5H429	-	-

Synonyms

Synonyms	Comment	Organism
Dbr2	-	Artemisia annua

Expression

Organism	Comment	Expression
Artemisia annua	three jasmonate-responsive transcription factors, ethylene response factor 1, ethylene response factor 2, and octadecanoidresponsive AP2/ERF, all transcriptionally activate the expression of artemisinin biosynthetic genes, such as amorpha-4,11-diene synthase (ADS), CYP71AV1, DBR2, and aldehyde dehydrogenase 1 (ALDH1). Cold stress indirectly activates the DBR2 expression by increasing the amount of jasmonate through upregulation of jasmonate biosynthetic genes (LOX1, LOX2, allene oxide cyclase [AOC], and jasmonate resistant 1 [JAR1]). Levels of artemisinin and related secondary metabolites, such as dihydroartemisinic acid, artemisinin B, and artemisinic acid, are increased in Artemisia annua under cold stress	up

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Release 2023.1 (January 2023)