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Literature summary for 1.3.1.90 extracted from

  • Xing, F.; Hiley, S.L.; Hughes, T.R.; Phizicky, E.M.
    The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs (2004), J. Biol. Chem., 279, 17850-17860.
    View publication on PubMed
Search for more literature for 1.3.1.90

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil20a in tRNA + NAD(P)H + H+ Saccharomyces cerevisiae the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr 5,6-dihydrouracil20b in tRNA + NAD(P)+
-
 ?
uracil20b in tRNA + NAD(P)H + H+ Saccharomyces cerevisiae the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr 5,6-dihydrouracil20b in tRNA + NAD(P)+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q06063
-
-

Reaction

Reaction Comment Organism Reaction ID
5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+ (1) Saccharomyces cerevisiae
a
5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+ (2) Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil20a in tRNA + NAD(P)H + H+ the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr Saccharomyces cerevisiae 5,6-dihydrouracil20b in tRNA + NAD(P)+
-
 ?
uracil20a in tRNA + NAD(P)H + H+ e.g. tRNALeu(CAA) or tRNATyr Saccharomyces cerevisiae 5,6-dihydrouracil20a in tRNA + NAD(P)+
-
 ?
uracil20b in tRNA + NAD(P)H + H+ the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr Saccharomyces cerevisiae 5,6-dihydrouracil20b in tRNA + NAD(P)+
-
 ?
uracil20b in tRNA + NAD(P)H + H+ e.g. tRNALeu(CAA) or tRNATyr Saccharomyces cerevisiae 5,6-dihydrouracil20b in tRNA + NAD(P)+
-
 ?

Synonyms

Synonyms Comment Organism
Dus4p
-
 Saccharomyces cerevisiae
tRNA-dihydrouridine synthase 4
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast Saccharomyces cerevisiae