Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-([1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl)-4-methylpiperazine | i.e. BM-212 | Mycobacterium tuberculosis | |
additional information | not inhibited by N-(4-phenyl-1,3-thiazol-2-yl)-4-(1H-pyrrol-1-yl)benzamide | Mycobacterium tuberculosis | |
N-(2,6-dichlorophenyl)-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide | 31% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
N-(2-aminophenyl)-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide | 12% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
N-(4-aminophenyl)-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide | 30% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
N-benzyl-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide | 12% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
N-[2-methyl-5-phenyl-3-([4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl)-1H-pyrrol-1-yl]pyridine-4-carboxamide | i.e. LL3858 | Mycobacterium tuberculosis | |
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-(1H-pyrrol-1-yl)benzamide | 25% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4-(2,5-dimethyl-1Hpyrrol-1-yl)benzamide | 38% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-4-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide | 38% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-4-(1H-pyrrol-1-yl)benzamide | 30% inhibition at 0.05 mM, 35% inhibition at 0.005 mM | Mycobacterium tuberculosis | |
opiniazide | - |
Mycobacterium tuberculosis | |
phtivazid | - |
Mycobacterium tuberculosis | |
triclosan | more than 99% inhibition at 0.05 mM | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-enoyl-[acyl-carrier protein] + NADH | Mycobacterium tuberculosis | - |
acyl-[acyl-carrier protein] + NAD+ | - |
? | |
trans-2-enoyl-[acyl-carrier protein] + NADH | Mycobacterium tuberculosis H37Rv | - |
acyl-[acyl-carrier protein] + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WGR1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WGR1 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography, and Superdex 200 gel filtration | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-dodecenoyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis | dodecanoyl-CoA + NAD+ | - |
? | |
trans-2-dodecenoyl-CoA + NADH + H+ | - |
Mycobacterium tuberculosis H37Rv | dodecanoyl-CoA + NAD+ | - |
? | |
trans-2-enoyl-[acyl-carrier protein] + NADH | - |
Mycobacterium tuberculosis | acyl-[acyl-carrier protein] + NAD+ | - |
? | |
trans-2-enoyl-[acyl-carrier protein] + NADH | - |
Mycobacterium tuberculosis H37Rv | acyl-[acyl-carrier protein] + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl acyl carrier protein reductase | - |
Mycobacterium tuberculosis |
ENR | - |
Mycobacterium tuberculosis |
InhA | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
metabolism | main enzyme for type II fatty acid synthesis | Mycobacterium tuberculosis |