Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[4-[4-(4-chloro-2-hydroxyphenoxy)phenyl]piperazin-1-yl]ethan-1-one | 25% inhibition 0.001 mM | Toxoplasma gondii | |
1-[5-(4-chloro-2-hydroxyphenoxy)thiophen-2-yl]propan-1-one | 75% inhibition 0.001 mM | Toxoplasma gondii | |
5-(4-chloro-2-hydroxyphenoxy)-N-(5-methyl-1,2-oxazol-3-yl)furan-2-carboxamide | 90% inhibition 0.001 mM | Toxoplasma gondii | |
5-(4-chloro-2-hydroxyphenoxy)-N-methylfuran-2-carboxamide | 46% inhibition 0.001 mM | Toxoplasma gondii | |
5-(4-chloro-2-hydroxyphenoxy)-N-[4-(prop-1-en-2-yl)piperazin-1-yl]furan-2-carboxamide | 45% inhibition 0.001 mM | Toxoplasma gondii | |
5-(4-chloro-2-hydroxyphenoxy)furan-2-carboxylic acid | 79% inhibition 0.001 mM | Toxoplasma gondii | |
5-(4-chloro-2-hydroxyphenoxy)thiophene-2-carboxylic acid | 48% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[(5-[[4-(prop-1-en-2-yl)piperazin-1-yl]methyl]thiophen-2-yl)oxy]phenol | 73% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[(naphthalen-2-yl)oxy]phenol | 91% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[(quinolin-6-yl)oxy]phenol | 87% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[2-chloro-4-(trifluoromethyl)phenoxy]phenol | 95% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[4-(4-methylpiperazin-1-yl)phenoxy]phenol | 81% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[4-(morpholin-4-yl)phenoxy]phenol | 74% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[4-(piperidine-1-sulfonyl)phenoxy]phenol | 78% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[4-(pyrrolidine-1-sulfonyl)phenoxy]phenol | 81% inhibition 0.001 mM | Toxoplasma gondii | |
5-chloro-2-[4-[(4-methylpiperazin-1-yl)methyl]phenoxy]phenol | 32% inhibition 0.001 mM | Toxoplasma gondii | |
N-(4-chloro-2-hydroxyphenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide | 27% inhibition 0.001 mM | Toxoplasma gondii | |
tert-butyl 4-[5-(4-chloro-2-hydroxyphenoxy)thiophene-2-carbonyl]piperazine-1-carboxylate | 76% inhibition 0.001 mM | Toxoplasma gondii | |
triclosan | 98% inhibition at 0.001 mM | Toxoplasma gondii | |
[5-(4-chloro-2-hydroxyphenoxy)thiophen-2-yl](piperazin-1-yl)methanone | 60% inhibition 0.001 mM | Toxoplasma gondii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-enoyl-[acyl-carrier protein] + NADH + H+ | Toxoplasma gondii | - |
acyl-[acyl-carrier protein] + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-enoyl-[acyl-carrier protein] + NADH + H+ | - |
Toxoplasma gondii | acyl-[acyl-carrier protein] + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-ACP reductase | - |
Toxoplasma gondii |
enoyl-acyl carrier protein | - |
Toxoplasma gondii |
ENR | - |
Toxoplasma gondii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Toxoplasma gondii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000015 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | triclosan | |
0.00003 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | 5-chloro-2-[2-chloro-4-(trifluoromethyl)phenoxy]phenol | |
0.000041 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | 5-chloro-2-[(naphthalen-2-yl)oxy]phenol | |
0.000058 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | 5-(4-chloro-2-hydroxyphenoxy)-N-(5-methyl-1,2-oxazol-3-yl)furan-2-carboxamide | |
0.000135 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | 5-chloro-2-[(quinolin-6-yl)oxy]phenol | |
0.000225 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | 5-chloro-2-[4-(4-methylpiperazin-1-yl)phenoxy]phenol | |
0.000965 | - |
pH and temperature not specified in the publication | Toxoplasma gondii | 5-chloro-2-[(5-[[4-(prop-1-en-2-yl)piperazin-1-yl]methyl]thiophen-2-yl)oxy]phenol |