Literature summary for 1.3.1.9 extracted from

Jordan, C.A.; Sandoval, B.A.; Serobyan, M.V.; Gilling, D.H.; Groziak, M.P.; Xu, H.H.; Vey, J.L.
Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors (2015), Acta Crystallogr. Sect. F, 71, 1521-1530.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Escherichia coli

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 100 mM citrate pH 7.0, 100 mM ammonium sulfate, 22% (w/v) PEG 3350	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
1-hydroxy-2,3,1-benzodiazaborinine-2(1H)-carbothioamide	-	Escherichia coli
2-(toluene-4-sulfonyl)-2H-benzo[d][1,2,3]diazaborinin-1-ol	-	Escherichia coli
2-methylsulfonyl-6-methylbenzodiazaborine	-	Escherichia coli
2-methylsulfonyl-benzodiazaborine	-	Escherichia coli
2-[amino(hydroxy)methyl]-2,3,1-benzodiazaborinin-1(2H)-ol	-	Escherichia coli
5,11-dimethyl-8H-[2,3,1]benzodiazaborinino[2',1':5,6][1,3,5,2,6]oxadiazadiborinino[2,3-a][2,3,1]benzodiazaborinin-8-one	-	Escherichia coli
6-methyl-2(propane-1-sulfonyl)-2H-thieno[3,2-d][1,2,3]diazaborinin-1-ol	-	Escherichia coli
diazaborine	-	Escherichia coli
triclosan	-	Escherichia coli
[oxydi(2,3,1-benzodiazaborinine-1,2-diyl)]bis[(pyridin-4-yl)methanone]	-	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0AEK4	-	-

Purification (Commentary)

Purification (Comment)	Organism
HisTrap column chromatography	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
crotonyl-CoA + NADH + H+	-	Escherichia coli	butyryl-CoA + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
enoyl-ACP reductase	-	Escherichia coli
enoyl-acyl carrier protein reductase	-	Escherichia coli
ENR	-	Escherichia coli
FabI	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Escherichia coli

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Release 2023.1 (January 2023)