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Literature summary for 1.3.1.9 extracted from

  • de Medeiros, P.S.; Ducati, R.G.; Basso, L.A.; Santos, D.S.; da Silva, L.H.
    Enzyme mechanism and slow-onset inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase by an inorganic complex (2011), Enzyme Res., 2011, 642758.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
pentacyano (isoniazid)ferrate-II [FeII(CN)5(INH)]3+, slow onset inhibitor Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.063
-
crotonyl-CoA pH 7.5, 25°C Plasmodium falciparum
0.085
-
NADH pH 7.5, 25°C Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Reaction

Reaction Comment Organism Reaction ID
an acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ double displacement mechanism. In this mechanism, a catalytic event occurs after the binding of NADH to free enzyme, generating and releasing NAD+ into solution prior to the binding of crotonoyl-CoA to a modified form of the enzyme, followed by formation of butyryl-CoA and regeneration of free enzyme Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-CoA + NADH + H+
-
Plasmodium falciparum butyryl-CoA + NAD+
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.2
-
crotonyl-CoA pH 7.5, 25°C Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.04
-
pentacyano (isoniazid)ferrate-II pH 7.5, 25°C Plasmodium falciparum

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
73
-
NADH pH 7.5, 25°C Plasmodium falciparum
98
-
crotonyl-CoA pH 7.5, 25°C Plasmodium falciparum